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Metabolism of liriodendrin and syringin by human intestinal bacteria and their relation toin vitro cytotoxicity

Abstract

When liriodendrin or syringin was incubated for 24 h with human intestinal bacteria, two metabolites, (+)-syringaresinol-β-d-glucopyranoside and (+)-syringaresinol, from liriodendrin and one metabolite, synapyl alcohol, from syringin were produced. The metabolic time course of liriodendrin was as follows: at early time, liriodendrin was converted to (+)-syringaresinol-β-d-glucopyranoside, and then (+)-syringaresinol. Thein vitro cytotoxicities of these metabolites, (+)-syringaresinol and synapyl alcohol, were superior to those of liriodendrin and syringin.

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Correspondence to Dong-Hyun Kim.

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Kim, D., Lee, K.T., Bae, E. et al. Metabolism of liriodendrin and syringin by human intestinal bacteria and their relation toin vitro cytotoxicity. Arch Pharm Res 22, 30–34 (1999). https://doi.org/10.1007/BF02976432

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Key words

  • Liriodendrin
  • Syringin
  • Intestinal bacteria
  • Cytotoxicity