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Biotransformation of dehydroparadols byAspergillus niger

Abstract

To prove uniqueness of allylic alcohol formation from α,β-unsaturated ketones by mammal enzymes, a metabolic pattern of dehydroparadols, non-pungent synthetic analogs of shogaol byAspergillus niger was examined. Two biotransformation products of a dehydroparadol, 1-(4-hydroxy-3-methoxyphenyl)-non-1-en-3-one were accumulated in the culture broth ofA. niger. They were characterized as 1-(4-hydroxy-3-methoxyphenyl)-non-1-en-9-ol-3-one and 1-(4-hydroxy-3-methoxyphenyl)-nonan-9-ol-3-one by UV, NMR and mass spectroscopic analyses. Accumulation of allylic alcohol metabolites was not observed.

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References Cited

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Correspondence to Sang-Sup Lee.

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Lee, S., Lee, W. Biotransformation of dehydroparadols byAspergillus niger . Arch. Pharm. Res. 18, 458–461 (1995). https://doi.org/10.1007/BF02976352

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Key words

  • Dehydroparadol
  • ω-Hydroxyparadol
  • ω-Hydroxydehydroparadol
  • Metabolic pattern of dehydroparadol
  • Aspergillus niger
  • Biotransformation