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Synthesis andIn vitro cytotoxicity of 4-alkyl- or 4-arylaminosub-stituted cyclopenta[c]quinoline derivatives

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Twelve 4-substituted cyclopenta[c]quinoline derivatives were synthesized and evaluatedin vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The compounds6c and6e bearing p-anisidine and pyrrolidine side chain were more active than the others.

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Correspondence to Heesoon Lee or Jeeman Lee or Sung-ll Yang.

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Lee, H., Lee, J. & Yang, S. Synthesis andIn vitro cytotoxicity of 4-alkyl- or 4-arylaminosub-stituted cyclopenta[c]quinoline derivatives. Arch Pharm Res 24, 385 (2001). https://doi.org/10.1007/BF02975180

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Key words

  • Antitumor agents
  • Cyclopentaquinoline derivatives
  • Cytotoxic activity
  • Doxorubicin
  • TAS-103