Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Synthesis andIn vitro cytotoxicity of 4-alkyl- or 4-arylaminosub-stituted cyclopenta[c]quinoline derivatives

  • 61 Accesses

  • 5 Citations

Abstract

Twelve 4-substituted cyclopenta[c]quinoline derivatives were synthesized and evaluatedin vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The compounds6c and6e bearing p-anisidine and pyrrolidine side chain were more active than the others.

This is a preview of subscription content, log in to check access.

References

  1. Aoyagi, Y., Kobunai, T., Utsugi, T., Oh-hara, T., and Yamada, Y.,In vitro antitumor activity of TAS-103, a novel quinoline derivative that targets topoisomerases I and II.Jpn. J. Cancer Res., 90, 578–587 (1999) and references cited therein

  2. Kaslow, C. E., and Sommer, N. B., Substituted Lepidines.J. Am. Chem. Soc., 68, 644–646 (1946).

  3. Lee, H., Lee, J., Hong, S-. S., Yang, S-. I., Jung, S.- H., Jahng, Y., and Cho, J., Synthesis andIn Vitro Cytotoxicity of 2-Alkylaminosubstituted Quinoline Derivatives.Arch. Pharm. Res., 23, 450–454, (2000).

  4. Minderman, H., Wrzosek, C., Cao, S. S., Utsugi, T., Kobunai, T., Yamada, Y., and Rustum, Y. M., Mechanism of action of the dual topoisomerase-l and -II inhibitor TAS-103 and activity against (multi)drug resistant cells.Cancer Chemother. Pharmacol., 45, 78–84 (2000) and references cited therein.

  5. Potts, K. T., Bhattachaarjee, D., and Walsh, E. B., Cyclo-addition Routes to Azaanthraquinone Derivatives. 1. Use of Azadienophiles.J. Org. Chem., 51, 2011–2021 (1986).

  6. Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenny, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening.J. Natl. Cancer Inst., 82, 1107–1112 (1990).

Download references

Author information

Correspondence to Heesoon Lee or Jeeman Lee or Sung-ll Yang.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lee, H., Lee, J. & Yang, S. Synthesis andIn vitro cytotoxicity of 4-alkyl- or 4-arylaminosub-stituted cyclopenta[c]quinoline derivatives. Arch Pharm Res 24, 385 (2001). https://doi.org/10.1007/BF02975180

Download citation

Key words

  • Antitumor agents
  • Cyclopentaquinoline derivatives
  • Cytotoxic activity
  • Doxorubicin
  • TAS-103