Twelve 4-substituted cyclopenta[c]quinoline derivatives were synthesized and evaluatedin vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The compounds6c and6e bearing p-anisidine and pyrrolidine side chain were more active than the others.
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Aoyagi, Y., Kobunai, T., Utsugi, T., Oh-hara, T., and Yamada, Y.,In vitro antitumor activity of TAS-103, a novel quinoline derivative that targets topoisomerases I and II.Jpn. J. Cancer Res., 90, 578–587 (1999) and references cited therein
Kaslow, C. E., and Sommer, N. B., Substituted Lepidines.J. Am. Chem. Soc., 68, 644–646 (1946).
Lee, H., Lee, J., Hong, S-. S., Yang, S-. I., Jung, S.- H., Jahng, Y., and Cho, J., Synthesis andIn Vitro Cytotoxicity of 2-Alkylaminosubstituted Quinoline Derivatives.Arch. Pharm. Res., 23, 450–454, (2000).
Minderman, H., Wrzosek, C., Cao, S. S., Utsugi, T., Kobunai, T., Yamada, Y., and Rustum, Y. M., Mechanism of action of the dual topoisomerase-l and -II inhibitor TAS-103 and activity against (multi)drug resistant cells.Cancer Chemother. Pharmacol., 45, 78–84 (2000) and references cited therein.
Potts, K. T., Bhattachaarjee, D., and Walsh, E. B., Cyclo-addition Routes to Azaanthraquinone Derivatives. 1. Use of Azadienophiles.J. Org. Chem., 51, 2011–2021 (1986).
Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenny, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening.J. Natl. Cancer Inst., 82, 1107–1112 (1990).
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Lee, H., Lee, J. & Yang, S. Synthesis andIn vitro cytotoxicity of 4-alkyl- or 4-arylaminosub-stituted cyclopenta[c]quinoline derivatives. Arch Pharm Res 24, 385 (2001). https://doi.org/10.1007/BF02975180
- Antitumor agents
- Cyclopentaquinoline derivatives
- Cytotoxic activity