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Synthesis of 2-alkyl-substituted-N6-methyladenine derivatives as potential adenosine receptor ligand

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2-(1-Hexynyl), 2-((E)-1-hexenyl) and 2-(n-hexyl)-N6-methyladenines were synthesized, starting from 2-amino-6-chloropurine using palladium-catalyzed coupling as a key step as potential adenosine receptor ligand.

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Correspondence to Hea Ok Kim.

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Kim, H.O. Synthesis of 2-alkyl-substituted-N6-methyladenine derivatives as potential adenosine receptor ligand. Arch Pharm Res 24, 508–513 (2001).

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Key words

  • Adenosine receptor
  • Palladium-catalyzed coupling