Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Anti-Diabetic activities of fucosterol fromPelvetia siliquosa

Abstract

Fucosterol isolated fromPelvetia siliquosa was tested for its anti-diabetic activityin vivo. Fucosterol, when administered orally at 30 mg/kg in streptozotocin-induced diabetic rats, was caused a significant decrease in serum glucose concentrations, and exhibited an inhibition of sorbitol accumulations in the lenses. Fucosterol, when administered orally at 300 mg/kg in epinephrine-induced diabetic rats, was also caused an inhibition of blood glucose level and glycogen degradation. These results demonstrated that fucosterol is a main anti-diabetic principle from the marine algaeP. siliquosa.

This is a preview of subscription content, log in to check access.

References

  1. Clements, R. S., Morrison, A. D., and Winegard, A. I., Polyol pathway in aorta: regulation by hormones.Science, 166, 1007–1008 (1969).

  2. Drabkin, D. S. and Ausin, J. H., Spectrophotometric constants for common hemoglobin derivatives in human, dog, and rabbit blood.J. Biol. Chem., 98, 719 (1932).

  3. Johnson, J. A. and Fusaro, R. M., The quantitative enzymatic determination of animal liver glycogen.Anal. Biochem., 15, 140–149 (1966).

  4. Kreisman, S. H., Ah Mew, N., Arsenault, M., Nessim, S. J., Halter, J. B., Vranic, M., and Marliss, E. B., Epinephrine infusion during moderate intensity exercise increases glucose production and uptake.Am. J. Physiol. Endocrinol. Metab., 278, E949-E957 (2000).

  5. Lee, S., Lee, Y. S., Jung, S. H., Kang, S. S., and Shin, K. H., Anti-oxidant activities of fucosterol from the marine algaePelvetia siliquosa.Arch. Pharm. Res., 26, 719–722 (2003).

  6. Lee, Y. S., Jung, S. H., Lee, S., Choi, Y. J., and Shin, K. H., Hepatoprotective and anti-diabetic effects ofPelvetia siliquosa, a marine algae, in rats.J. Appl. Pharmacol., 10, 165–169 (2002).

  7. Mariam, A., Asmawi, M. Z., and Sadikun., Hypoglycemic activity of the aqueous extract ofOrthosiphon stamineus.Fitoterapia, 57, 465–468 (1996).

  8. Oh, Y. S., Lee, I. K., and Boo, S. M., An annotated account of Korean economic seaweeds for food, medical and industrial uses.Kor. J. Phycol., 5, 57–71 (1990).

  9. Trinder, P. Determination of glucose using glucose oxidase with an alternative oxygen acceptor.Ann. Clin. Biochem., 6, 24–27 (1969).

  10. Yoon, J. T., Developmental morphology on the regeneration ofPelvetia siliquosa Tseng et Chang, Phaeophyta in Korea. Chonbuk National University. Ph. D. Thesis (1995).

Download references

Author information

Correspondence to Yeon Sil Lee or Kuk Hyun Shin or Bak-Kwang Kim or Sanghyun Lee.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lee, Y.S., Shin, K.H., Kim, B. et al. Anti-Diabetic activities of fucosterol fromPelvetia siliquosa . Arch Pharm Res 27, 1120–1122 (2004). https://doi.org/10.1007/BF02975115

Download citation

Key words

  • Pelvetia siliquosa
  • Fucaceae
  • Fucosterol
  • Anti-diabetic activity