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Allogeneic peripheral blood stem cell transplantation in the treatment of leukemia

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Abstract

We reported 14 leukemia patients transplanted with allogeneic peripheral blood stem cells (Allo-PBSCT) of HLA identical sibling, AML 5, ALL 4, CML 5. There were 12 patients in their early stage of leukemia, 2 in late stage. They were 32 (25–42) years old, 10 male and 4 female. After conditioned with CTX and fTBI, G/GM-CSF mobilized donor’s peripheral blood mononuclear cells (MNC) 4.80 (2.46–8.43)×108/kg and CD34+ cells 3.96 (1.01–10.08)x106/kg were infused respectively. CSA and MTX used as GVHD prophylaxis. After Allo-PBSCT, WBC rose to 1.0×109/L on day+17 (+12−+26) and platelet rose to 50×109/L on day +27 (+19−+35) respectively. The blood products support, the antibiotics used, and total environment protection duration decreased. Acute GVHD presented in 7 patients (50.0%). Four patients died in acute GVHD and infection on days of +73, +41 +57 and +49. The disease free survival days after Allo-PBSCT in the 10 patients was +137 (+91–+240) days. It is suggested that Allo-PBSCT probably has some advantage than that of Allo-BMT.

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Correspondence to Luxian Cao.

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Cao, L., Hu, L., Chen, H. et al. Allogeneic peripheral blood stem cell transplantation in the treatment of leukemia. Chin J Cancer Res 9, 142–145 (1997). https://doi.org/10.1007/BF02974682

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Key words

  • Leukemia
  • PBSCT
  • Allogeneic