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Allogeneic peripheral blood stem cell transplantation in the treatment of leukemia

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We reported 14 leukemia patients transplanted with allogeneic peripheral blood stem cells (Allo-PBSCT) of HLA identical sibling, AML 5, ALL 4, CML 5. There were 12 patients in their early stage of leukemia, 2 in late stage. They were 32 (25–42) years old, 10 male and 4 female. After conditioned with CTX and fTBI, G/GM-CSF mobilized donor’s peripheral blood mononuclear cells (MNC) 4.80 (2.46–8.43)×108/kg and CD34+ cells 3.96 (1.01–10.08)x106/kg were infused respectively. CSA and MTX used as GVHD prophylaxis. After Allo-PBSCT, WBC rose to 1.0×109/L on day+17 (+12−+26) and platelet rose to 50×109/L on day +27 (+19−+35) respectively. The blood products support, the antibiotics used, and total environment protection duration decreased. Acute GVHD presented in 7 patients (50.0%). Four patients died in acute GVHD and infection on days of +73, +41 +57 and +49. The disease free survival days after Allo-PBSCT in the 10 patients was +137 (+91–+240) days. It is suggested that Allo-PBSCT probably has some advantage than that of Allo-BMT.

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  1. 1.

    Kessinger A, Smith DM, Standjord SE, et al. Allogeneic transplantation of blood-derived, T cell-depleted hemopoietic stem cells after myeloablative treatment in a patient with acute lymphoblastic leukemia. Bone Marrow Transplant 1989; 4:643.

  2. 2.

    Korbling M, Huh YO, Durett A, et al. Allogeneic blood stem cell transplantation: Peripheralization and yield of donor-derived primitive haematopoietic progenitor cells (CD34+ Thy-ldim) and lymphoid subsets, and possible predictors of engraftment and Graft-Versus-Host Disease. Blood 1995; 86: 2842.

  3. 3.

    Fliedner TM. Blood stem cell transplantation: From preclinical to clinical models. Stem Cells 1995; 13: (Suppl 3) 1.

  4. 4.

    Richman CM, Weimer RS, Yankee RS. Increase in circulating stem cells following chemotherapy in man. Blood 1967; 47: 1034.

  5. 5.

    Sheridan WP, Begley CG, Juttner CA, et al. Effect of peripheral-blood progenitor cells mobilized by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy. Lancet 1992; 339:640.

  6. 6.

    Gratwohl A, Hermans J, Baidomero H. Haematopoietic precursor cell transplants in Europe: Activity in 1994. Report from the European Group for blood and marrow transplantation (EBMT). Bone marrow Transplant 1996; 17:137.

  7. 7.

    Goldman J. Peripheral blood stem cells for allografting. Blood 1995; 85:1413.

  8. 8.

    Azevedo WM, Aranha FJP, Gouvea JV, et al. Allogeneic transplantation with blood stem cells mobilized by rhG-CSF for hematological malignancies. Bone Marrow Transplant 1995; 16:61.

  9. 9.

    Knapp W, Strobl H, Scheinecker C, et al. Molecular characterization of CD34 human hematopoietic progenitor cells. Ann Hematol 1995; 70:281.

  10. 10.

    Weaver CH, Longin K, Buckner CD, et al. Lymphocyte content in peripheral blood mononuclear cells collected after the administration of recombinant human granulocyte colony stimulating factor. bone Marrow Transplant 1994; 13:411.

  11. 11.

    Atkinson K, Farrell C, Champman G, et al. Female marrow donors increase the risk of acute graft-versus-host disease: effect of donor age and parity and analysis of cell subpopulations in the donor marrow inoculum. Br J Hematol 1986; 63:231.

  12. 12.

    Majolino I, Saglio G. Scime R, et al. High incidence of chronic GVHD after primary allogeneic peripheral blood stem cell transplantation in patients with hematologic malignancies. Bone Marrow Transplant 1996; 17:555.

  13. 13.

    Auquier P, Macquart-Moulin G, Moatti JP, et al. Cjomparison of anxiety, pain and discomfort in two procedures of hematopoietic stem cell collection: leukacytapheresis and bone marrow harvest. Bone Marrow Transplant 1995; 16:541.

  14. 14.

    Murphy WJ, Retbikds CW, Tiberghien P, et al. Natural killer cells and bone marrow transplantation. J Natl Cancer Inst 1993; 85:1475.

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Correspondence to Luxian Cao.

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Cao, L., Hu, L., Chen, H. et al. Allogeneic peripheral blood stem cell transplantation in the treatment of leukemia. Chin J Cancer Res 9, 142–145 (1997). https://doi.org/10.1007/BF02974682

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Key words

  • Leukemia
  • Allogeneic