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Antitumor triterpenes from medicinal plants

Abstract

Thirteen kinds of naturally occurring or derivatised triterpenes, reported to have an antitumoral property, were reinvestigated on the basis of their direct cytotoxicity or the inhibitory activity on cell growth against five kinds of cultured human tumor cells,i. e., A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15,in vitro. Ursonic acidIII, betulinic acidVIII, betulonic acidX and glycyrrhetinic acidXI were exhibited a marked inhibition on cell growth.

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Correspondence to Shi Yong Ryu.

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Ryu, S.Y., Choi, S.U., Lee, S.H. et al. Antitumor triterpenes from medicinal plants. Arch. Pharm. Res. 17, 375 (1994). https://doi.org/10.1007/BF02974180

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Key words

  • Triterpene
  • Antitumor
  • Betulinic acid
  • Betulonic acid
  • Ursonic acid
  • Glycyrrhetinic acid