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Antiviral triterpenes fromPrunella vulgaris

Abstract

Two triterpenes 1 and 2 with antiviral activity againstHerpes simplex virus type 1in vitro were isolated fromPrunella vulgaris. Each compound caused a significant reduction in viral cytopathic effect whenvero cells were exposed to them for 72 hours after viral challenge. They were identified asbetulinic acid(1) and 2α, 3α-dihydroxyurs-12-en-28-oic acid(2) on the basis of their spectroscopic properties. The antiviral activity of them was estimated as EC50=30 μg/ml(1) and 8 μg/ml(2), respectively by plaque reduction assay.

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Correspondence to Shi Yong Ryu or Chong-Kyo Lee or Chong Ock Lee or Hae Soo Kim or Ok Pyo Zee.

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Ryu, S.Y., Lee, C., Lee, C.O. et al. Antiviral triterpenes fromPrunella vulgaris . Arch. Pharm. Res. 15, 242–245 (1992). https://doi.org/10.1007/BF02974063

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Keywords

  • Prunella vulgaris
  • Labiatae
  • betulinic acid
  • 2α,3α-dihydroxyurs-12-en-28-oic acid
  • antiviral
  • Herpes simplex