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Effects of squalene on the immune responses in mice(II): Cellular and non-specific immune response and antitumor activity of squalene

Abstract

Effects of squalene on cellular and non-specific immune responses and antitumor activity in mice were investigated. Cellular and non-specific immunological assay parameters adopted in the present study were delayed-type hypersensitivity reaction and rosette forming cells (RFC) for cellular immunity, activities of natural killer (NK) cells and phagocyte for non-specific immunity. Squalene resulted in marked increases of cellular and non-specific immune functions and enhancement of host resistance to tumor challenge in dose-dependent manner.

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Correspondence to Young Keun Ahn.

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Ahn, Y.K., Kim, J.H. Effects of squalene on the immune responses in mice(II): Cellular and non-specific immune response and antitumor activity of squalene. Arch. Pharm. Res. 15, 20–29 (1992). https://doi.org/10.1007/BF02973979

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Keywords

  • Squalene
  • delayed-type hypersensitivity reaction
  • rosette forming cell
  • natural killer cell activity
  • phagocytic activity
  • host resistance to tumor challenge