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Pathological significance of santorini’s duct of the pancreas

Signification pathologique du canal de Santorini

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The pathological significance of the duct of Santorini has been studied on the basis of ERCP studies. Decompression function of the duct could be established by radiomorphological analysis and by changes in blood enzyme levels that followed endoscopic pancreatography. While diffuse fibrosis of the pancreatic parenchyma in chronic pancreatitis may interfere with this role of the duct of Santorini, increased pressure in the main duct is unequivocally offset by the accessory duct if fibrosis is absent. Thus Santorini's duct may be regarded not merely as a simple congenital variation but rather as an important connection between the main pancreatic duct and the duodenum, which may fulfill protective functions.


La signification pathologique du canal de Santorini a été étudiée à partir de l'ERCP. La fonction de décompression du canal a pu être établie par analyse radiomorphologique et par les modifications des dosages enzymatiques sanguins qui ont suivi la pancréatographie endoscopique. Alors que la fibrose diffuse du parenchyme pancréatique dans les cas de pancréatite chronique peut avoir une influence sur ce rôle du canal de Santorini, en cas de pression accrue dans le canal principal, le canal accessoire exerce un phénomène de compensation incontestable, s'il n'y a pas de fibrose. Par conséquent, le canal de Santorini ne doit pas seulement être considéré comme une simple modification congénitale mais plutôt comme une liaison importante entre le canal pancréatique principal et le duodénum, pouvant assurer de véritables fonctions de protection.

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Correspondence to Z. Tulassay.

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Tulassay, Z., Papp, J., Kollin, E. et al. Pathological significance of santorini’s duct of the pancreas. Acta Endosc 10, 365 (1980). https://doi.org/10.1007/BF02973525

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  • ERCP
  • pancreatic morphology
  • duct of Santorini


  • ERCP
  • morphologie pancréatique
  • canal de Santorini