Objective: To investigate the mechanism of Astragalus-Angelica Mixture (AAM) ’s effects on lipid metabolism disturbance in nephrotic rats.Methods: To examine the effects of AAM on serum albumin, lipid levels, and activities of lipoprotein lipase (LPL) and lecithin-cholesterol acyltransferase (LCAT), which are key enzymes for metabolism of lipid in immune-induced nephrotic hyperlipidemia rats and exogenous hyperlipidemia rats.Results: In nephrotic rats, serum albumin was reduced, lipid increased significantly, LPL activity decreased markedly and the LCAT activity was relatively insufficient. Activities of LPL and LCAT increased obviously in AAM treated nephrotic rats. There were no change of activities of LPL and LCAT in exogenous hyperlipidemia rats and AAM showed no effect on the activities of these two enzymes.Conclusion: The effect of AAM on regulating lipid metabolism might be due to enhance the clearance of both triglyceride-rich and cholesterol-rich apoB containing lipoprotein by improving the activities of LPL and LCAT.
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Lu Y, Li JZ, Zheng X, et al. Effect of Astragalus-Angelica Mixture on serum lipids and glomerulosclerosis in rats with nephrotic syndrome. CJIM 1997; 17(8):478- 480.
WEI MJ, chief-editor. Examination of urinary protein. Clinical Examination (2nd Edition). Beijing: Science and Technology Literature Press, 1994:152.
Krans RM, Levy RI, Fredrickson DS, et al. Selective measurement of two different triglyceride lipase activities in rat postheparin plasma. J Lipid Research 1973; 14:286 -295.
Wu CZ, Cai HJ, Li ZX, et al. Changes of two plasma lipase activities and serum HDL after heparin injection. Chin J Cardiovas 1984; 12(2): 144–146.
Shanghai Institute of Medical Assay, chief-editor. Determination of free fatty acid. Clinical biochemical testing technique (Vol.1) 1st Edition. Shanghai: Shanghai Science and Technology Press, 1997:168–170.
Zhang XY, Cui RL, Li L, et al. Modified LCAT determination and its clinical significance in nephropathy. Nephropathy, Dialysis and Kidney Transplantation 1995; 4: 18.
Hitrano T, Ebara T, Furekawa S, et al. Mechanism of hypertriglyceridemia in Dahl Salt-sensitive rats, an animal model of spontaneous nephrotic syndrome. Metabolism 1994;43:248–256.
Subbaiah PV, Rodby RA. Abnormal acyltransferase activities and accelerated cholesterol ester transfer in patients with nephrotic syndrome. Metabolism 1994;43:1126–1133.
Wheeler DV, Bernard DB. Lipid abnormalities in the nephrotic syndrome: causes, consequences and treatment. AJKD 1994;23:331–346.
Wang HY, Li JZ, Yu H, et al. Effect of Tripterygium and Astragalus-Angelica on permeability of glomerular filtration membrane of microlesion in nephropathic rats. CMJ 1988; 68(9):513–515.
Li LY, Chen MH, Tong TJ, et al. The molecular basis of Chinese herbs (Astragali and Angelica) on increasing serum albumin synthesis in nephrotic rats. Nephrology 1998;4:1–6.
This study was supported by National Natural Science Foundation (No. 39670909)
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Li, N., Li, J., Xin, G. et al. Effect of astragalus- angelica mixture on lipoprotein lipase and lecithin- cholesterol acyltransferase of nephrotic rats. CJIM 6, 35–37 (2000). https://doi.org/10.1007/BF02973145
- Astragalus-Angelica Mixture
- nephrotic syndrome
- lipoprotein lipase
- lecithin-cholesterol acyltransferase