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Synthesis of 5-aminolevulinic acid (ALA) and itst-butyl ester for the fluorescence detection of early cancer

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Abstract

5-Aminolevulinic acid and its derivatives, which are known to affect the early diagnosis and treatment of cancer, have been synthesized. Simple methods for the synthesis of 5-aminolevulinic acid (ALA), a precursor of porphyrins, have been developed in our laboratory for use in studies on the biosynthesis of porphyrins.

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References

  1. Andreas, P. and Saeed, A., Synthesis of-aminoketones via selective reduction of cyanides.Tetrahedron Lett., 25, 2977–2980 (1984).

  2. Cortese, D. A., Pairolero, P. C., Bergstrath, E. J., Woolner, L. B., Uhlenhopp, M. A., Piehler, J. M., Sanderson, D. R., Bernatz, P. E., Williams, D. E., Taylor, W. F., Payne, W. S., and Fontana, R. S., Roentgenographically occult lung cancer.J. Thorac. Cardiovasc. Surgery, 86, 373–380 (1983).

  3. Fontana, R. S., Sanderson, D. R., Woolner, L. B., Taylor, W. F., Miller, W. E., Muhm, J. R., Bernatz, P. E., Payne, W. S., Pairolero, P. C., and Bergstalh, E. J., Screening for lung cancer.Cancer, 67, 1155–1164 (1991).

  4. Katsumi, I. and Masahiro, K., Synthesis of13C- and15N-multilabeled 5-aminolevulinic acid.J. Label Compd. Radiopharm., 45, 139–143 (2002).

  5. Robert, W. W. and Alsoph, H. C., The hydrogenation of oxaloacetone. A new synthesis of thioimidazolylpropionic acid, Contribution from the chemical laboratories of the Johns Hopkins Univ.

  6. Rudolf, M. H., Gamarra, F., Hautmann, H., Haubinger, K., Wagner, S., Castro, M., and Baumgartner, R., 5-Aminolevulinic acid for the fluorosence detection of bronchial tumors.Diagnosis and Therapeutic Endoscopy, 5, 113–118 (1999).

  7. Yoshihisa, N., Tamami, N., Masataka, A., Kazuyoshi, Y., Masakazu, Y., and Hiroshi, T., Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome.Pharmacol. Res., 50, 65–76 (2004).

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Correspondence to Jin-Hyun Jeong.

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Kang, M., Kim, D., Kim, J.S. et al. Synthesis of 5-aminolevulinic acid (ALA) and itst-butyl ester for the fluorescence detection of early cancer. Arch Pharm Res 28, 1111–1113 (2005). https://doi.org/10.1007/BF02972970

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Key words

  • 5-Aminolevulinic acid
  • Fluorescence detection
  • ALA
  • PDT