The oral administration of extracts of young radishes cultivated with sulfur after intravenous tumor cell injection achieved a marked reduction of pulmonary colonization in mice. Treatment of the mice with extracts of young radish cultivated with sulfur did not show any increase in the number of CD8+ or NK T cells in the spleen, indicating no influence on host immunity. Sulforaphane, which could be a candidate for an active compound from young radishes cultivated with sulfur, inhibited cell growth of B16-F10 melanoma cells. In addition, extracts of the young radish cultivated with sulfur-fed group showed enhanced quinine reductase (QR) activities in the liver and lung and a slight increase of glutathione S-transferase (GST) activity in the liver. These results suggested that the administration of extracts of young radishes cultivated with sulfur suppressed pulmonary tumorigenesis, possibly due to increased activity of detoxification enzymes in the liver and lung, and partly due to cell cytotoxicity.
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Chung, F. L., Conaway, C. C., Rao, C. V., and Reddy, B. S., Chemoprevention of colonic aberrant cryptic foci in Fisher Rats by sulforaphane and phenethyl isothiocyanate.Carcinogenesis, 21, 2287–2291 (2000).
Fahey, J. W., Haristory, X., Dolan, P. M., Kensler, T. W., Scholtus, I., Stephenson, K. K., Talay, P., and Lozniewski, A., Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains ofHelicobacter pyroli and prevents benzo[a]pyrene-induced stomach tumors.Proc. Natl. Acad. Sci. U.S.A., 99, 7610–7615 (2002).
Finley, J. W., Davis, C. D. and Feng, Y., Selenium from high selenium broccoli protects rats from colon cancer.J. Nutr., 130, 2384–2389 (2000).
Gao, X., Dinkova-Kostyova, A. T., and Talalay, P., Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforaphane.Proc Natl. Acad. Sci. U.S.A., 98, 15221–15226 (2001).
Haenszel, W., Locke, F. B. and Segi, M., A case control study of large bowel cancer in Japan.J. Natl. Cancer Inst., 64, 17–22 (1980).
Hecht, S. S., Inhibition of carcinogenesis by isothiocyanates.Drug Metab. Rev., 32, 395–411 (2000).
Kim, K. A., Rho, C. W., Choi, K. R., Hwang, H. J., and Choi, H. S., Quinone Reductase Inducer from Radish Leaf Cultivated in the Soil Containing Sulfur.J. Korean Soc. Food Sci. Nutr., 33, 946–950 (2004).
Posner, G. H., Cho, C. G., Green, J. V., Zhang, Y., and Talalay, P., Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes.J. Med. Chem., 37, 170–176 (1994).
Watenberg, L. W., In Cancer chemoprevention. Eds: Wattenberg, M., Lipkin, C. W., Boone, C. W., and Kelloff, F. L., CRC Press, Boca Raton, pp. 19–30, (1992).
Wortelboer, H. M., DeKruif, C. A., Van Lersel, A. A. J., Noorhoek, H. M., Blaauboer, B. J., Van Bladeren, P. J., and Flake, H. E., Effects of cooked Brussels sprouts on cP450 profile and phase II enzymes in liver and small intestinal mucosa of the rat.Food Chem. Toxicol., 30, 589–599 (1992).
Zhang, Y., Talalay, P., Cho, C. G., and Posner, G. H., A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.Proc. Natl. Acad. Sci. U.S.A., 89, 2399–2403 (1992).
Zhang, Y., Kensler, T. W., Cho, C.-G., posner, G. H., and Talay, P., Anticarcinogenic activities of sulforaphane and structurally related synthetic norbonyl isothiocyanates.Proc. Natl. Acad. Sci. U.S.A., 91, 3147–3150 (1994).
Zhang, Y. and Talalay, P., Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanism.Cancer Res. (suppl), 54, 1976s-1981s (1994).
Zhang, Y. and Talay, P., Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic phase 2 enzymes.Cancer Res., 58, 4632–4639 (1998).
Zhang, Y., Svehlikova, V., Bao Y., Howie, A. F., Beckett, G. J., and Williamson, G., Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.Carcinogenesis, 24, 497–503 (2003).
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Kim, S., Kim, B., Kyung, T. et al. Suppressive effects of young radish cultivated with sulfur on growth and metastasis of B16-F10 melanoma cells. Arch Pharm Res 29, 235–240 (2006). https://doi.org/10.1007/BF02969399
- Quinone reductase