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Two Cases of Cholesterol Granuloma of the Breast

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We report two cases of cholesterol granuloma of the breast clinically diagnosed as malignant and describe the features.

The first patient was a 74-year-old woman who complained of a lump in the left breast. The mammography and ultrasonography suggested a malignant mass. Fine needle aspiration showed multinucleated giant cells. We suspected breast cancer, but cholesterol granuloma was diagnosed on excisional biopsy. The second case was a 51-year-old woman who was found to have a breast tumor on a screening mammography. The mammography and ultrasonography suggested carcinoma, but excisional biopsy revealed cholesterol granuloma.

Reports of cholesterol granuloma of the breast are very rare. Cholesterol granuloma should be considered in the differential diagnosis of breast carcinoma.

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  1. 1)

    Nast CC, Cohen AH: Renal cholesterol granulomas, identification and morphological pattern of development.Histopathology 9:1195–1204, 1985.

  2. 2)

    Lin JL, Tseng CH, Marsidi PJ,et al: Cholesterol granuloma of right testis.Urology 14:522–523, 1979.

  3. 3)

    Al-Amer AF, Walia HS, Madda JP: Cholesterol granuloma of the peritoneum.Can J Surg 33:410–413, 1990.

  4. 4)

    Bundgaard N, Eriksen HE, Greisen O: Inflamed adenolymphoma with cholesterol granuloma.J Laryngol Otol 101:967–970, 1987.

  5. 5)

    Rubinstein A, Brenner S: Idiopathic lipogranulomatosis of spleen and periaortic lymph nodes with noncaseating granulomas of the liver.Hum Pathol 13:1133–1135, 1982.

  6. 6)

    Doring L, Wedemeier G: Cholesteringranulom der weiblichen Brust.Chirung 45:502–521, 1974.

  7. 7)

    Wilhelmus JL, Schrodt GR, Mahaffey LM: Choles terol granulomas of the breast: A lesion which clinically mimics carcinoma.Am J Clin Pathol 77:592–597, 1982.

  8. 8)

    Reynolds HE, Cramer HM: Cholesterol granuloma of the breast: a mimic of carcinoma.Radiology 191:249–250, 1994.

  9. 9)

    Smith GL, Hicks P, Wijesinghe DP,et al: Cholesterol granuloma of the breast presenting an intracystic papilloma.British J Radiol 70:1178–1179, 1997.

  10. 10)

    Tsuji H, Satoh Y, Ohtsuka K,et al: A case of choles terol granuloma of the breast.Gekashinnryou 7:1107–1110, 1989.

  11. 11)

    Nager GT, Vanderveen TS: Cholesterol granuloma involving the temporal bone.Ann Otol Rhinol Laryn gol 85:204–209, 1976.

  12. 12)

    Page DL, Anderson TJ: Miscellaneous non-neoplastic conditions. In: Diagnostic histopathology of the breast, Churchill Livingstone, New York, pp62–64, 1987.

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Correspondence to Masahiro Ishizaki or Shozo Ohsumi or Shigemitsu Takashima or Koichi Mandai.

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Ishizaki, M., Ohsumi, S., Takashima, S. et al. Two Cases of Cholesterol Granuloma of the Breast. Breast Cancer 8, 158–161 (2001). https://doi.org/10.1007/BF02967496

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Key words

  • Cholesterol
  • Granuloma
  • Breast