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A case of breast cancer metastasizing to cervix after resection of pancreatic metastasis


A case of breast cancer that metastasized to the cervix 10 years and 8 months after mastectomy is reported. The patient had undergone pancreaticoduodenectomy due to solitary metastasis to the head of the pancreas 4 years previously. The cervical metastasis was associated with abnormal genital bleeding. After pancreaticoduodenectomy the serum levels of CEA, CA15-3 and NCC-ST-439, which are markers of breast cancer, were within normal limits, but the serum level of CA15-3 had increased month by month. The patient had abnormal genital bleeding and presented to the department of gynecology at our hospital. The tumor was in the cervix, bled easily and 2.5 × 2.0 cm in size on ultrasonography. It was thought to be carcinoma of the cervix, but biopsy revealed the tumor to be an adenocarcinoma pathologically and CA15-3 was immunohistochemically demonstrated in the resected specimen, similar to lobular carcinoma of the breast. Abdominal CT scan revealed involvement of the ovaries and uterus, prompting hysterectomy with bilateral oophorectomy. After discharge, she received chemoendocrine therapy. However, she subsequently died due to peritoneal carcinomatosis.

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Author information

Correspondence to Akihiro Ogino or Tadashi Nomizu or Kenji Gonnda or Chiyo Okouchi or Takeshi Sakuma or Mutsuo Yamada or Naoto Katagata or Fumiaki Watanabe or Yoshiko Yamaguchi or Takao Yoshida.

Additional information

Reprint requests to Akihiro Ogino, Department of Surgery, Hoshi General Hospital, 2-1-16 Omachi, Koriyama 963-8501, Japan.

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Ogino, A., Nomizu, T., Gonnda, K. et al. A case of breast cancer metastasizing to cervix after resection of pancreatic metastasis. Breast Cancer 10, 284 (2003). https://doi.org/10.1007/BF02966731

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Key words

  • Recurrent breast cancer
  • Metastasis to cervix
  • Uterus
  • Metastasis to head of pancreas
  • Lobular carcinoma