A case of breast cancer that metastasized to the cervix 10 years and 8 months after mastectomy is reported. The patient had undergone pancreaticoduodenectomy due to solitary metastasis to the head of the pancreas 4 years previously. The cervical metastasis was associated with abnormal genital bleeding. After pancreaticoduodenectomy the serum levels of CEA, CA15-3 and NCC-ST-439, which are markers of breast cancer, were within normal limits, but the serum level of CA15-3 had increased month by month. The patient had abnormal genital bleeding and presented to the department of gynecology at our hospital. The tumor was in the cervix, bled easily and 2.5 × 2.0 cm in size on ultrasonography. It was thought to be carcinoma of the cervix, but biopsy revealed the tumor to be an adenocarcinoma pathologically and CA15-3 was immunohistochemically demonstrated in the resected specimen, similar to lobular carcinoma of the breast. Abdominal CT scan revealed involvement of the ovaries and uterus, prompting hysterectomy with bilateral oophorectomy. After discharge, she received chemoendocrine therapy. However, she subsequently died due to peritoneal carcinomatosis.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
X ray photography
Abrams HL, Spiro R, Goldstein N: Metastases in carcinoma; Analysis of 1000 autopsied cases.Cancer 3:74–85, 1950.
Kozuka S, Tubota M, Taki T: Pathology of metastatic cancer in the pancreas. Tan to Sui (J Biliary Tract Pancreas) 1:1531–1535, 1980 (in Japanese).
Pappo I, Feigin E, Uziely B, Amir G: Biliary, and pancreatic metastases of breast carcinoma; Is surgical palliation indicated?J Surg Oncol 46:211–214, 1991.
Mehta SA, Jagannath P, Krishnamurthy SC, DE Souza LJ: Isolated pancreatic metastasis from locally controlled breast cancer; A case report.Indian J Cancer 28:48–50, 1991.
Mountney J, Maury AC, Jackson AM, Coleman RE, Johnson AG: Pancreatic metastases from breast cancer; An unusual cause of biliary obstruction.Eur J Surg Oncol 23:574–576, 1997.
Legg JW: Melanotic sarcoma of the eyeball; secondary growth in the organs of the chest and belly, particularly in the liver.Trans Pathol Soc London 29:225–230, 1878.
Charache H: Metastatic carcinoma in the uterus.Am J Surg 53:152–157, 1941.
Kumar NB, Hart WR: Metastases to the uterine corpus from extragenital cancers; a clinicopathologic study of 63 cases.Cancer 50:2163–2169, 1982.
Stemmermann GN: Extrapelvic carcinoma metastatic to the uterus.Am J Obstet Gynecol 82:1261–1266, 1961.
Piura B, Bar-David J, Goldstein J: Abnormal uterine bleeding as a presenting sign of metastatic signet ring cell carcinoma originating in the breast; case report.Br J Obstet Gynaecol 92:645–648, 1985.
Piura B, Yanai-Inbar I, Rabinovich A, Zalmanov S, Goldstein J: Abnormal uterine bleeding as a presenting sign of metastases to the uterine corpus, cervix and vagina in a breast cancer patient on tamoxifen therapy.Eur J Obstet Gynecol 83:57–61, 1999.
Maymon R, Czernobilsky B, Lifschitz-Mercer B, Schneider D, Bukovsky I, David A: Metastatic breast carcinoma manifesting as postmenopausal Uterine bleeding in a patient on tamoxifen therapy.Eur J Gynecol Oncol 17:319–321, 1996.
Kidney DD, Cohen AJ, Butler J: Abdominal metastases of infiltrating lobular breast carcinoma; CT and fluoroscopic imaging findings.Abdom Imaging 22:156–159, 1997.
Watanabe F, Nomizu T, Katagata N, Yamaki Y, Saito T, Tsuchiya A, Abe R: A case of retroperitoneal metastasis of breast cancer.Jpn J Breast Cancer 13:808–812, 1998 (in Japanese with English abstract).
Nomizu T, Katagata N, Matsuoka T, Suzuki S, Yabuta T, Watanabe F, Yamaki Y, Saito T, Tsuchiya A, Abe R: A case of breast cancer metastatic to the head of the pancreas.Breast Cancer 6:131–134, 1999.
Hilkens J, Buus F, Hilgers J, Hageman Ph, Calafat J, Sonnenberg A, Valk M: Monoclonal antibodies against human milkfat globule membranes detecting differentiation antigens of the mammary gland and its tumor.Int J Cancer 34:197–206, 1984.
Kufe D, Inghirami G, Abe M: Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors.Hybridoma 3:223–231, 1984.
Nomizu T, Nihei M, Suzuki S, Ishii Y, Ando Y, Tsuchiya A, Abe R: Clinical study of CA15-3 in breast cancer as the indicator on the decision of efficacy of treatment in advanced or recurrent breast cancer.Fukushima Med J 36:427–431, 1986 (in Japanese with English summary).
Ohuchi N, Sato S, Akimoto M, Taira Y, Matoba N, Takahashi K, Mori S: The correlation between the immunohistochemical expression of DF3 antigen and serum CA15-3 in breast cancer patients.Jpn J Surg 21:129–137, 1991.
Nomizu T, Kanno M, Watanabe T, Watanabe F, Suzuki S, Tsuchiya A, Yamaki Y, Taeda Y, Ohuchi N, Saito T, Abe R: A case of breast cancer metastatic to the pituitary gland.Breast Cancer 3:71–74, 1996.
Reprint requests to Akihiro Ogino, Department of Surgery, Hoshi General Hospital, 2-1-16 Omachi, Koriyama 963-8501, Japan.
About this article
Cite this article
Ogino, A., Nomizu, T., Gonnda, K. et al. A case of breast cancer metastasizing to cervix after resection of pancreatic metastasis. Breast Cancer 10, 284 (2003). https://doi.org/10.1007/BF02966731
- Recurrent breast cancer
- Metastasis to cervix
- Metastasis to head of pancreas
- Lobular carcinoma