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High dose melphalan with autologous bone marrow transpantation in the treatment of metastatic Ewing’s sarcoma

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A 17 year old boy was treated with combination chemotherapy and radiotherapy for Ewing’s sarcoma of the right humerus. Two months after the completion of chemotherapy he re-presented with recurrence at the primary site and metastases in the lung, humurus and lumbar vertebrae. Following amputation of the right arm he was treated with melpalan 300 mg I.V. followed by autologous bone marrow transplantation. The procedure was well tolerated and was followed by disappearance of the pulmonary and lumbar metastatic lesions. Relapse of metastatic lesions occurred 16 weeks following the high dose melphalan therapy.

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Correspondence to S. R. McCann.

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McCann, S.R., Reynolds, M., Meldrum, R. et al. High dose melphalan with autologous bone marrow transpantation in the treatment of metastatic Ewing’s sarcoma. Ir J Med Sci 152, 160–164 (1983). https://doi.org/10.1007/BF02960061

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  • Autologous Bone Marrow
  • Autologous Bone Marrow Transplantation
  • Erythroid Progenitor
  • High Dose Melphalan
  • Folinic Acid Rescue