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High dose melphalan with autologous bone marrow transpantation in the treatment of metastatic Ewing’s sarcoma

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Summary

A 17 year old boy was treated with combination chemotherapy and radiotherapy for Ewing’s sarcoma of the right humerus. Two months after the completion of chemotherapy he re-presented with recurrence at the primary site and metastases in the lung, humurus and lumbar vertebrae. Following amputation of the right arm he was treated with melpalan 300 mg I.V. followed by autologous bone marrow transplantation. The procedure was well tolerated and was followed by disappearance of the pulmonary and lumbar metastatic lesions. Relapse of metastatic lesions occurred 16 weeks following the high dose melphalan therapy.

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References

  1. Cornbleet, M. A., Corringham, R. E. T., Prentice, H. G., Boesen, E. M. and McElwain, T. J. 1981. Treatment of Ewing’s Sarcoma with highdose Melphalan and autologous Bone Marrow Transplantation. Cancer Treatment Reports. 65, 241.

  2. Deisseroth, A., Abrams, U., Bode, D., Colbert, D., Fontana, J., Holihan, T. and Wright, D. 1980. Current status of autologous bone marrow transplantation. Biology of Bone Marrow Transplantation. Eds.: R. P. Gale and C. F. Fox. Academic Press. p. 45.

  3. Hedley, D. W., McElwain, T. J., Millar, L. and Gordon, M. Y. 1978. Acceleration of bone marrow recovery by pre-treatment with cyclophosphamide in patients receiving high dose Helphalan. ancet. ii, 966.

  4. Iscove, N. N., Sieber, F., Winterhalter, K. H. 1974. Erythroid colony formation in cultures of mouse and human marrow: Analysis of the requirement for erythropoietin by gel filtration and affinity chromatography on agarose-concanavalin A. J. Cell. Physiol. 83, 309.

  5. McElwain, T. J., Hedley, D. W., Burton, G.et al 1979. Marrow autotransplantation accelerated haematological recovery in patients with malignant melanoma treated with high-dose Melphalan. Br. J. Cancer. 40, 72.

  6. Pike, B. L. and Robinson, W. A. 1970. Human bone marrow colony growth in agar gel. J. Cell Physiol. 76, 77.

  7. Schlunk, J. and Schleyer, M. 1980. The influence of culture conditions on the production of colony-stimulating activity of human placenta. Exp. Hemat. Vol. 8. No. 2. 179.

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Correspondence to S. R. McCann.

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McCann, S.R., Reynolds, M., Meldrum, R. et al. High dose melphalan with autologous bone marrow transpantation in the treatment of metastatic Ewing’s sarcoma. Ir J Med Sci 152, 160–164 (1983). https://doi.org/10.1007/BF02960061

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Keywords

  • Autologous Bone Marrow
  • Autologous Bone Marrow Transplantation
  • Erythroid Progenitor
  • High Dose Melphalan
  • Folinic Acid Rescue