This report concerns a young man who developed jaundice and anuria following ingestion of phenylbutazone. In addition to light microscopical findings, details of the ultrastructural changes in the kidney are described.
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Ganote, C. E., Reimer, K. A. and Jennings, R. B. 1974. Acute mercuric chloride nephrotoxicity. An electron microscopic and metabolic study. Lab. Invest. 31, 633.
Kleinman, J. G., Breitenfield, R. V. and Roth, D. A. 1980. Acute renal failure associated with acetaminophen ingestion: report of a case review of the literature. Clin. Nephrol. 14, 4, 201.
Lipsett, M. B. and Goldman, R. 1954. Phenylbutazone toxicity: report of a case of acute renal failure. Ann. Int. Med. 41, 1075.
Morales, A. and Steyn, J. 1971. Papillary necrosis following phenylbutazone ingestion. Arch. Surg. 103, 420.
Oliver, J., MacDowell, M., Tracy, A. 1951. The pathogenesis of acute renal failure associated with traumatic and toxic injury. Renal ischaemia, nephrotoxic damage and the ischaemic episode. J. Clin. Invest. 30, 1307–1440.
Preuss, H. G., Tourkantonis, A., Hsu, C. H., Shim, P. S., Barzyk, P., Tio, F. and Schreiner, G. E. 1975. Early events in various forms of experimental acute tubular necrosis in rats. Lab. Invest. 32, 286.
Richardson, J. H. and Alderfer, H. H. 1963. Acute renal failure caused by phenylbutazone. New Eng. J. Med. 268, 809.
Scheitlin, W. and Jaenneret, P. 1957. Uber akute Nierenschdigungen unter Phenylbutazontherapie 1957. Schweiz med. Wchschr. 87, 881.
Schreiner, G. E. and Maher, J. F. 1965. Toxic nephropathy. Amer. J. Med. 38, 409.
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Doyle, G.D., Campbell, E., Gavin, N. et al. Phenylbutazone nephrotoxicity — A light and electron microscopic study. I.J.M.S. 152, 435–439 (1983). https://doi.org/10.1007/BF02958705
- Acute Renal Failure
- Status Epilepticus
- Proximal Tubule
- Tubular Basement Membrane