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The inhibition of gastric acid secretion by gastric mucus

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Intravenous administration of an extract of gastric mucus inhibits the secretion of gastric acid.

Local irrigation of canine gastric pouches with Eugenol increases the secretion of gastric mucus, inhibits the histamine-stimulated secretion of acid, but has no effect on pepsin activity.

Acetylcholine has a similar but less marked effect.

Repeated applications of Eugenol do not interfere with acid production from gastric pouches.

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  1. Anson, M. L.,J. Gen. Physiol., 1938, 22, 79.

  2. Atkinson, A. J., J.A.M.A., 1932, 98, 1153.

  3. Bolton, C., and Goodhard, G. W.,J. Physiol., 1933, 77, 287.

  4. Brunschwig, A., Rasmussen, R. A., Camp., E. J., and Moe, R.,Surgery, 1942, 12, 887.

  5. Code, C. F., Blackburn, C. M., Livermore, G. R., and Ratke, H. V.,Gastroenterology, 1949, 13, 573.

  6. Fogelson, S. J., J.A.M.A., 1931, 96, 673.

  7. Glass, G. B. J., and Boyd, L. J.,Gastroenterology, 1950, 16, 697.

  8. Hollander, F., and Lauber, F. U.,Proc. Soc. Exp. Biol. Med., 1948, 67, 34.

  9. Kim, M. S., and Ivy, A. C., J.A.M.A., 1931, 97, 1511.

  10. Menguy, R., and Smith, W. O.,Proc. Soc. Exp. Biol. Med., 1959, 102, 665.

  11. Morrison, L. M.,Am. J. Dig. Dis., 1945, 12, 328.

  12. Smith, W. O., Duval, M. K., Joel. W., Houska, W. L., and Wolff, S.,Gastroenterology, 1960, 39, 55.

  13. Wolff, S., and Wolff, H. G.,Gastroenterology, 1948, 10, 251.

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Author information

Correspondence to Ivan D. A. Johnston M.Ch., F.R.C.S..

Additional information

Based on a paper read before the Surgical Section of the Royal Academy of Medicine in March, 1960.

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Johnston, I.D.A., Wilbur, D.W. The inhibition of gastric acid secretion by gastric mucus. Ir J Med Sci 37, 236–241 (1962). https://doi.org/10.1007/BF02956980

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