The impact of lead as an environmental pollutant on the I-131 uptake and retention in rat thyroid was assayed alone and in combination with lithium treatment. Lead treatment significantly stimulated the 2- and 24-h uptake of I-131 in the thyroid, and the 24-h uptake showed the maximum stimulation after 3 mo of lead treatment. On the contrary, lithium supplementation reduced the uptake significantly and the maximum decrease was noticed after 2 mo of lithium administration. Further, simultaneous lead and lithium treatment resulted in more pronounced increase in the uptake of I-131 by the thyroid, which was maximum after 3 mo of combined treatment. The thyroidal biological half-life of I-131 (T biol) was found to be increased significantly following lead and lithium treatments when given separately. Interestingly, combined lead and lithium treatment given up to 2 mo further prolonged theT biol of I-131, thus reflecting its increased retention.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
R. Klein,Pediatr. Clin. N. Am. 21, 277–290 (1974).
R. W. Baldoh,Arch. Environ. Health 28, 198–208 (1974).
D. Stofen,J. Mol. Cell Cardiol. 6, 285–290 (1974).
P. Scoppa, M. Roumengous, and W. Penning,Experientia 29, 970–972 (1973).
J. Chisoln,J. Pediatr. 60, 1–17 (1962).
T. J. Sobotka, R. E. Brodie, and M. P. Cook,Toxicology 5, 175–191 (1975).
T. C. Dubas, A. Stevenson, R. L. Singhal, and P. D. Hrdina,Toxicology 9, 185–191 (1975).
S. Hariguchi,Osaka City Med. J. 33, 51–56 (1987).
M. Schou,J. Psychiat. Res. 6, 67–95 (1968).
M. Schou, A. Amdisen, S. E. Jensen, and T. Olsen,Br. Med. J. 3, 710–713 (1968).
G. Sedvall, B. Jonsson, U. Pettersson, and H. Levin,Life Sci. 7, 1257–1264 (1968).
J. G. Turner, B. E. W. Brownlie, and T. G. H. Rogers,Lancet i, 614–615 (1976).
D. Dhawan, R. Sharma, R. R. Sharma, and R. J. Dash,IRCS Med. Sci. 12, 541 (1974).
R. P. Hullin and A. W. Johnsson,Life Sci. 9, 9–20 (1970).
D. Dhawan, R. R. Sharma, R. Sharma, and R. J. Dash,Aust. J. Biol. Sci. 41, 387–392 (1988).
R. M. Refowitz,J. Occup. Med. 26, 579–582 (1984).
About this article
Cite this article
Singh, B., Dhawan, D., Chand, B. et al. Biokinetics of iodine-131 in rat thyroid following lead and lithium supplementation. Biol Trace Elem Res 40, 287 (1994). https://doi.org/10.1007/BF02950801
- Lead treatment
- lithium treatment
- biological half-life (T biol)