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Biokinetics of iodine-131 in rat thyroid following lead and lithium supplementation

Abstract

The impact of lead as an environmental pollutant on the I-131 uptake and retention in rat thyroid was assayed alone and in combination with lithium treatment. Lead treatment significantly stimulated the 2- and 24-h uptake of I-131 in the thyroid, and the 24-h uptake showed the maximum stimulation after 3 mo of lead treatment. On the contrary, lithium supplementation reduced the uptake significantly and the maximum decrease was noticed after 2 mo of lithium administration. Further, simultaneous lead and lithium treatment resulted in more pronounced increase in the uptake of I-131 by the thyroid, which was maximum after 3 mo of combined treatment. The thyroidal biological half-life of I-131 (T biol) was found to be increased significantly following lead and lithium treatments when given separately. Interestingly, combined lead and lithium treatment given up to 2 mo further prolonged theT biol of I-131, thus reflecting its increased retention.

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Correspondence to Devinder Dhawan.

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Singh, B., Dhawan, D., Chand, B. et al. Biokinetics of iodine-131 in rat thyroid following lead and lithium supplementation. Biol Trace Elem Res 40, 287 (1994). https://doi.org/10.1007/BF02950801

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Index Entries

  • Lead treatment
  • lithium treatment
  • thyroid
  • Iodine-131
  • uptake
  • biological half-life (T biol)