Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Prevalence of abnormal thyroid function tests in a Down’s syndrome population

Abstract

As thyroid function has been documented to be of a higher prevalence in individuals with Down’s syndrome, a study was set up to assess the thyroid status of these individuals. Thyroid function tests (T.F.T.s) were initially reviewed on 100 individuals with Down’s syndrome in the community and on 36 individuals who were residentially based. Abnormal T.F.T.s were then reviewed 3 yr later. In total sample of 136, initially 13 per cent [n=18] of individuals with Down’s syndrome had abnormal T.F.T.s, 5 per cent [n=7] were established cases of thyroid disease and 8 per cent [n=11] were newly identified cases who had abnormal T.F.T.s. Three yr later 6.5 per cent [n=9] of the group who had had abnormal T.F.T.s continued to have abnormal T.F.T.s, 5 per cent [n=7] had thyroid disease and 1.5 per cent [n=2] still had biochemical evidence of thyroid dysfunction. There was a statistically significant increase in abnormal T.F.T.s in the residential sample compared to the community sample on both occasions.

The incidence of thyroid dysfunction has been found to increase with age, particularly over the age of 40, however in this study the majority were under the age of 40 with an age range between 28.3 yr and 33.8 yr. The results in this study, coupled with the variability of T.F.T.s over time, highlights the need for regular monitoring of the thyroid status of individuals with Down’s syndrome.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Lobo, E. H., Khan, M., Tew. Community study of hypothyroidism in Down’s syndrome. British Med. J. 1980; 280: 1253.

  2. 2.

    Suresh, T., Robertson, P. Thyroid dysfunction in adults with Down’s syndrome. Psychiatric Bulletin. 1993; 17: 477–478.

  3. 3.

    Sare, Z., Ruvalcaba, R. H. A., Kelley, V. C. Prevalence of thyroid disorder in Down’s syndrome. Clinical Genetics. 1978; 14: 154–158.

  4. 4.

    Mani, C. Hypothyroidism in Down’s syndrome. British J. Psychiatry. 1988; 153: 102–104.

  5. 5.

    Hollington, D. R., McKean, H. E., Reockel, I. Goitre, immunological observations and thyroid tests in Down’s syndrome. American J. Dis. Childhood. 1974; 127: 524–527.

  6. 6.

    Evered, D. C., Ormston, B. J., Smith, P. A., Hall, R., Bird, T. Grades of Hypothyroidism. British Med. J. 1973; i: 657.

  7. 7.

    Tunbridge, W. M. G., Evered, D. C., Hall, R., Appelton, D., Brewis, M., Clark, F., Grimley Evans, J., Young, E., Bird, T., Smith, P. A. Thyroid diseases in an English community. Proceedings of the 7th International Thyroid Conference, Amsterdam: Excerpta Medica. 1975.

Download references

Author information

Correspondence to S. Rooney.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rooney, S., Walsh, E. Prevalence of abnormal thyroid function tests in a Down’s syndrome population. I.J.M.S. 166, 80–82 (1997). https://doi.org/10.1007/BF02944192

Download citation

Keywords

  • Hypothyroidism
  • Hyperthyroidism
  • Thyroid Disease
  • Community Sample
  • Intellectual Disability