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Exercise and colon cancer: Primary and secondary prevention

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Abstract

Many studies have demonstrated the effects of exercise on both primary and secondary prevention of colon cancer. Exercise appears to have a dose-response reduction in the rate of colon cancer. The mechanism by which exercise provides this benefit is not known, but increase in insulin-like growth factor-binding protein and reduction of prostaglandins appear to be the likely cause. Once a person develops colon cancer the benefits of exercise appear to continue both by increasing quality of life and reducing cancer-specific and overall mortality.

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References and Recommended Reading

  1. 1.

    Lee IM:Physical activity and cancer prevention—data from epidemiologic studies.Med Sci Sports Exerc 2003,35:1823–1827.

  2. 2.

    Slattery ML, Edwards S, Curtin K, et al.:Physical activity and colorectal cancer.Am J Epidemiol 2003,158:214–224.

  3. 3.

    Chao A, Connell CJ, Jacobs EJ, et al.:Amount, type, and timing of recreational physical activity in relation to colon and rectal cancer in older adults: the Cancer Prevention Study II Nutrition Cohort.Cancer Epidemiol Biomarkers Prev 2004,13:2187–2195.

  4. 4.

    Zhang Y, Cantor KP, Dosemeci M, et al.:Occupational and leisure-time physical activity and risk of colon cancer by subsite.J Occup Environ Med 2006,48:236–243.

  5. 5.

    Lee IM, Paffenbarger RS Jr, Hsieh C:Physical activity and risk of developing colorectal cancer among college alumni.J Natl Cancer Inst 1991,83:1324–1329.

  6. 6.

    Martinez ME, Giovannucci E, Spiegelman D, et al.:Leisure-time physical activity, body size, and colon cancer in women. Nurses’ Health Study Research Group.J Natl Cancer Inst 1997,89:948–955.

  7. 7.

    Slattery ML:Physical activity and colorectal cancer.Sports Med 2004,34:239–252.

  8. 8.

    McTiernan A, Yasui Y, Sorensen B, et al.:Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial.Cancer Epidemiol Biomarkers Prev 2006,15:1588–1597.

  9. 9.

    Jenkins PJ, Bustin SA:Evidence for a link between IGF-I and cancer.Eur J Endocrinol 2004,151(Suppl 1):S17-S22.

  10. 10.

    Jenkins PJ, Frajese V, Jones AM, et al.:Insulin-like growth factor I and the development of colorectal neoplasia in acromegaly.J Clin Endocrinol Metab 2000,85:3218–3221.

  11. 11.

    Jenkins PJ:Cancer in acromegaly.Trends Endocrinol Metab 1998,9:360–366.

  12. 12.

    Wu Y, Yakar S, Zhao L, et al.:Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis.Cancer Res 2002,62:1030–1035.

  13. 13.

    Reinmuth N, Liu W, Fan F, et al.:Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer.Clin Cancer Res 2002,8:3259–3269.

  14. 14.

    Chadan SG, Dill RP, Vanderhoek K, Parkhouse WS:Influence of physical activity on plasma insulin-like growth factor-1 and insulin-like growth factor binding proteins in healthy older women.Mech Ageing Dev 1999,109:21–34.

  15. 15.

    Schmitz KH, Ahmed RL, Yee D:Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30–50-year-old women.Cancer Epidemiol Biomarkers Prev 2002,11:1597–1604.

  16. 16.

    Tang R, Wang JY, Lo SK, Hsieh LL:Physical activity, water intake and risk of colorectal cancer in Taiwan: a hospital-based case-control study.Int J Cancer 1999,82:484–489.

  17. 17.

    Leiper JB, Carnie A, Maughan RJ:Water turnover rates in sedentary and exercising middle aged men.Br J Sports Med 1996,30:24–26.

  18. 18.

    Shannon J, White E, Shattuck AL, Potter JD:Relation-ship of food groups and water intake to colon cancer risk.Cancer Epidemiol Biomarkers Prev 1996,5:495–502.

  19. 19.

    Murtaugh MA, Ma KN, Caan BJ, Slattery ML:Association of fluids from beverages with risk of rectal cancer.Nutr Cancer 2004,49:25–31.

  20. 20.

    Mutoh M, Takahashi M, Wakabayashi K:Roles of prostanoids in colon carcinogenesis and their potential targeting for cancer chemoprevention.Curr Pharm Des 2006,12:2375–2382.

  21. 21.

    Chan TA:Prostaglandins and the colon cancer connection.Trends Mol Med 2006,12:240–244.

  22. 22.

    Huls G, Koornstra JJ, Kleibeuker JH:Non-steroidal anti-inflammatory drugs and molecular carcinogenesis of colorectal carcinomas.Lancet 2003,362:230–232.

  23. 23.

    Martinez ME, Heddens D, Earnest DL, et al.:Physical activity, body mass index, and prostaglandin E2 levels in rectal mucosa.J Natl Cancer Inst 1999,91:950–953.

  24. 24.

    van Nieuwenhoven MA, Brouns F, Brummer RJ:The effect of physical exercise on parameters of gastrointestinal function.Neurogastroenterol Motil 1999,11:431–439.

  25. 25.

    Brouns F, Beckers E:Is the gut an athletic organ? Digestion, absorption and exercise.Sports Med 1993,15:242–257.

  26. 26.

    Moses FM:The effect of exercise on the gastrointestinal tract.Sports Med 1990,9:159–172.

  27. 27.

    MacLennan R, Jensen OM, Mosbech J, Vuori H:Diet, transit time, stool weight, and colon cancer in two Scandinavian populations.Am J Clin Nutr 1978,31(0 Suppl):S239-S242.

  28. 28.

    Cummings JH, Branch WJ, Bjerrum L, et al.:Colon cancer and large bowel function in Denmark and Finland.Nutr Cancer 1982,4:61–66.

  29. 29.

    Neff MJ, ACS:ACS releases guidelines on nutrition and physical activity during and after cancer treatment.Am Fam Physician 2004,69:1803–1805.

  30. 30.

    Satia JA, Campbell MK, Galanko JA, et al.:Longitudinal changes in lifestyle behaviors and health status in colon cancer survivors.Cancer Epidemiol Biomarkers Prev 2004,13:1022–1031.

  31. 31.

    Courneya KS:Exercise in cancer survivors: an overview of research.Med Sci Sports Exerc 2003,35:1846–1852.

  32. 32.

    Schmitz KH, Holtzman J, Courneya KS, et al.:Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis.Cancer Epidemiol Biomarkers Prev 2005,14:1588–1595.

  33. 33.

    McTiernan A:Physical activity after cancer: physiologic outcomes.Cancer Invest 2004,22:68–81.

  34. 34.

    Brown JK, Byers T, Doyle C, et al.:Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices.CA Cancer J Clin 2003,53:268–291.

  35. 35.

    Midtgaard J, Tveteras A, Rorth M, et al.:The impact of supervised exercise intervention on short-term postprogram leisure time physical activity level in cancer patients undergoing chemotherapy: 1- and 3-month follow-up on the body & cancer project.Palliat Support Care 2006,4:25–35.

  36. 36.

    Mustian KM, Griggs JJ, Morrow GR, et al.:Exercise and side effects among 749 patients during and after treatment for cancer: a University of Rochester Cancer Center Community Clinical Oncology Program Study.Support Care Cancer 2006,14:732–741.

  37. 37.

    Burnham TR, Wilcox A:Effects of exercise on physiological and psychological variables in cancer survivors.Med Sci Sports Exerc 2002,34:1863–1867.

  38. 38.

    Andersen C, Adamsen L, Moeller T, et al.:The effect of a multidimensional exercise programme on symptoms and side-effects in cancer patients undergoing chemotherapy — the use of semi-structured diaries.Eur J Oncol Nurs 2006,10:247–262.

  39. 39.

    Irwin ML, Ainsworth BE:Physical activity interventions following cancer diagnosis: methodologic challenges to delivery and assessment.Cancer Invest 2004,22:30–50.

  40. 40.

    Haydon AM, Macinnis RJ, English DR, et al.:Physical activity, insulin-like growth factor 1, insulin-like growth factor binding protein 3, and survival from colorectal cancer.Gut 2006,55:689–694.

  41. 41.

    Meyerhardt JA, Heseltine D, Niedzwiecki D, et al.:Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803.J Clin Oncol 2006,24:3535–3541.

  42. 42.

    Meyerhardt JA, Giovannucci EL, Holmes MD, et al.:Physical activity and survival after colorectal cancer diagnosis.J Clin Oncol 2006,24:3527–3534.

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Correspondence to Thomas H. Trojian MD.

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Trojian, T.H., Mody, K. & Chain, P. Exercise and colon cancer: Primary and secondary prevention. Curr Sports Med Rep 6, 120–124 (2007). https://doi.org/10.1007/BF02941153

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Keywords

  • Physical Activity
  • Colon Cancer
  • Acromegaly
  • Nurse Health Study
  • Colon Transit Time