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Paracetamol poisoning ’ hepatic protection by n-acetylcysteine

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Summary

Two cases of paracetamol poisoning are reported, where the early administration of n-acetylcysteine in one protected against the hepatic damage observed in the untreated case, when assessed both histologically as well as biochemically; it suggests this treatment is effective in the management of paracetamol poisoning.

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References

  1. Clark, R., Borirakchanyavat, V., Davidson, A. R., Thompson, R. P. H., Widdop B., Goulding, R., Williams, R. 1973. Hepatic Damage and Death from Overdose of Paracetamol. Lancet i, 66.

  2. Portmann B., Talbot, I. C. Davy, D. W., Davidson, A. R., Murray-Lyon, I. M., Williams, R. 1975. Histological Changes in the Liver Following a Paracetamol Overdose: Correlation with Clinical and Biochemical Parameters. J. Path. 117, 169.

  3. Prescott, L. F., Illingworth, R. N., Critchley, J. A. J. H., Stewart, M. J., Adam, R. D., Proudfoot, A. T. 1979. Intravenous n-Acetylcysteine: The Treatment of Choice. Brit. Med. J. 2, 1097.

  4. Vale, J. A., Meredith, T. J., Goulding, R. 1981. Treatment of Acetaminophen Poisoning: The Use of Oral Methionine. Arch. Intern. Med. 141, 394.

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Correspondence to J. Kirby or S. Rocha or J. F. Fielding.

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Requests for Reprints to J. F. Fielding.

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Kirby, J., Rocha, S. & Fielding, J.F. Paracetamol poisoning ’ hepatic protection by n-acetylcysteine. Ir J Med Sci 151, 353 (1982). https://doi.org/10.1007/BF02940223

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Keywords

  • Paracetamol
  • Acetylcysteine
  • Hepatic Damage
  • Paracetamol Overdose
  • Untreated Case