Irish Journal of Medical Science

, Volume 147, Issue 1, pp 308–312 | Cite as

Vibrio Cholerae neuraminidase susceptible n-acetyl neuraminic acid (sialic acid) levels in human leukaemia

  • Antoinette Hogan Ryan
  • J. J. Fennelly


Cell surface vibrio Cholerae neuraminidase (VCN) susceptible sialic acid has been studied in leucocytes of normal human subjects and patients with acute myeloid, acute lymphatic and chronic lymphatic leukaemia as well as in myeloid metaplasia. The mean VCN susceptible sialic acid released in normal lymphocytes was 222±72 n mole/109 cells as compared to 158±n mole/109 cells in leukaemic lymphocytes, and 178±48 n mole/109 cells in leukaemic granulocytes. This release of surface sialic acid by VCN may play a part in increasing immunogenicity of leukaemic cells for immunotherapy.


Sialic Acid Acute Myelogenous Leukaemia Normal Lymphocyte Leukaemic Cell Phate Buffer Saline 
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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Antoinette Hogan Ryan
    • 1
  • J. J. Fennelly
    • 1
  1. 1.Department of Medicine and TherapeuticsUniversity College and St. Vincent's HospitalDublin 4

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