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The binding of phenylbutazone to bovine and horse serum albumin

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Summary

Adynamic dialysis technique was used to study the protein binding of phenylbutazone to bovine and horse serum albumin. Data obtained indicates that the bovine serum albumin results are in general agreement with the previously published results. It was also found that the magnitude of binding of phenylbutazone to horse serum albumin was the same as that to bovine albumin.

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References

  1. Brodie, B. B. 1966. Pharmacological and Clinical Implications of Drug Transport in Transport Functions of Proteins. ed. by P. Desgrez and P. M. de Trowerse, Amsterdam. Elsevier. p. 137.

  2. Chien, Y. W., Lambert, H. J. and Karima, A. 1974. Comparative binding of disopyramide phosphate and quinidine sulfate to human plasma proteins. J. Pharm. Sci. 63, 1877.

  3. Chignell, C. F. and Starkweather, D. K. 1971. Species differences in the binding of phenylbutazone to plasma albumin. Pharmacol. 5, 235.

  4. Goto, S., Harta, T. and Yoshitomi, H. 1975. Effect of salicyclic acid on the binding of methyl orange and sulfisoxazole with bovine serum albumin. Yakuzaigaku, 35, 51.

  5. Jun, H. W., Luzzi, L. A. and Hsu, P. L. 1972. Phenylbutazone-sodium warfarin binding using a fluorescent probe technique. J. Pharm. Sci. 61, 1835.

  6. Kaneo, Y., Kai, A., Kiryu, S. and Iguchi, S. 1976. Protein binding of nonsteroidal anti-inflammatory agents. I. J. Pharm. Soc. Japan. 96, 1412.

  7. Klotz, I. M. and Hunston, D. L. 1971. Properties of graphical representation of multiple classes of binding sites. Biochem. 10, 3065.

  8. Lambert, M. B. T., Molloy, T. and Wilson, C. W. M. 1977a. The effect of aspirin on the protein binding of ascorbic acid. Br. J. Pharmac. 60, 300P.

  9. Lambert, M. B. T. and Evans, J. A. 1977b. The detection of phenylbutazone in the urine of the horse. Irish Vet. J. 31, 75.

  10. Meyer, M. C. and Guttman, D. E. 1968a. The binding of drugs by plasma protein. J. Pharm. Sci. 57, 895.

  11. Meyer, M. C. and Guttman, D. E. 1968b. Novel method for studying protein binding. J. Pharm. Sci. 57, 1627.

  12. Rudman, D., Bixler, II, T. J. and Del Rio, A. E. 1971. Effect of free fatty acids on binding of drugs by bovine serum albumin, by human serum albumin and by rabbit serum. J. Pharm. Exp. Ther. 176, 261.

  13. Scatchard, G. 1949. The attractions of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51, 660.

  14. Scatchard, G., Coleman, J. S. and Shen, A. L. 1956. Physical chemistry of protein solutions. VIII. The binding of some small anions to serum albumin. J. Am. Chem. Soc. 79, 12.

  15. Solomon, H. M., Schrogie, J. J. and Williams, D. 1968. The displacement of phenylbutazone-14C and warfarin-14c from human albumin by various drugs and fatty acids. Bioch. Pharm. 17, 143.

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Correspondence to M. B. T. Lambert.

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Lambert, M.B.T., Kelly, P.P. The binding of phenylbutazone to bovine and horse serum albumin. I.J.M.S. 147, 193–196 (1978). https://doi.org/10.1007/BF02939400

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Keywords

  • Methyl Orange
  • Disopyramide
  • Phenylbutazone
  • Sulfisoxazole
  • Butazone