In a comparative study in humans pituitary-adrenal and pituitary-thyroid function have been assessed following oral administration of difluocortolone and dexamethasone to groups of volunteers. The results of single dose and multi-dose studies demonstrate that on an equal dose basis difluocortolone is a less potent inhibitor of both functions than dexamethasone. During administration of the former drug adrenal steroids were less suppressed and following multi-dose administration recovery of pituitary adrenal function was more rapid than was the case with dexamethasone.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Arimura, A., Bowers, C. Y., Schally, A. V., Saito, M. and Miller, M. C. 1969. Effect of corticotrophin releasing factor, dexamethasone and actinomycin D on the release of ACTH from rat pituitary in vivo and in vitro. Endocrinology, 85, 300.
Beardwell, C. G., Burke, C. W. and Cope, C. L. 1968. Urinary free cortisol measured by competitive protein binding. J. Endocrinol. 42, 79.
Beisel, W. R., DiRaimonds, V. C. and Forsham, P. H. 1964. Cortisol transport and disappearance. Ann. Intern. Med. 60, 641.
Christy, N. P., Wallace, E. Z. and Jailer, J. H. 1956. Comparative effects of prednisone and cortisone in suppressing the response of the adrenal cortex to exogenous adrenocorticotrophin. J. Clin. Endocrinol. 16, 1059.
Cope, C. L. 1956. Diagnostic use of adrenal inhibition. Brit. Med. J. ii, 193.
Cope, C. L. and Black, E. G. 1959. The reliability of some adrenal function tests. Brit. Med. J. ii, 1117.
Cope, C. L. and Hurlock, B. 1954. Some aspects of adrenal cortical metabolism. Clin. Sci. 13, 69.
Critchlow, V. and Zimmermann, E. 1969. Negative feedback and pituitary-adrenal function in female rats. Amer. J. Physiol. 216, 148.
Dallman, M. F. and Yates, F. E. 1969. Dynamic asymmetries in the corticosteroid feedback path and distribution-metabolism-binding elements of the adrenocortical system. Ann. N.Y. Acad. Sci. 156. 696.
De Kloet, E. R., Van Der Vies, J. and De Wied, D. 1974. The site of the suppressive action of dexamethasone on pituitary-adrenal activity. Endocrinology, 94, 61.
De Wied, D. 1964. The site of the blocking action of dexamethasone on ACTH release. J. Endocrinol. 29, 29.
Duick, D. S., Warren, D. W., Nicoloff, J. T., Otis, C. L. and Croxson, M. S. 1975. Effect of single dose dexamethasone on the concentration of serum triiodothyronine in man. J. Clin. Endocrinol, 39, 1151.
Faglia, G. C., Ferrari, P., Beck-Peccoz, P., Spada, A., Travaglini, P. and Ambrosi, B. 1973. Reduced plasma thyrotropin response to thyrotropin-releasing hormone after dexamethasone administration in normal subjects. Hormone Metab. Res. 5, 289.
Few, J. D. 1961. A method for the analysis of urinary 17-hydroxy-corticosteroids. J. Endocrinol. 22, 31.
Ganong, W. F. 1970. In ‘The Hypothalamus’ ed by L. Martini, M. Motta and F. Franschini. New York, Academic Press, p. 317.
Haigler, E. D., Pittman, J. A., Hershman, J. M. and Baugh, C. M. 1971. Direct evaluation of pituitary thyrotropin reserve utilizing synthetic thyrotropin releasing hormone. J. Clin. Endocrinol. 33, 573.
Hesch, R. D. and Evered, D. 1973. Radioimmunoassay of triiodothyroinine in unextracted human serum. Brit. Med. J. i, 645.
Ingbar, S. H. and Freinkel, N. 1955. The influence of ACTH, cortisone and hydrocortisone on the distribution and peripheral metabolism of thyroxine. J. Clin. Invest. 34, 1375.
Ingbar, S. H. and Freinkel, N. 1956. ACTH, cortisone and the metabolism of iodine. Metabolism 5, 652.
Jacobson, T., Sundberg, M., Kotovirta, M. L. and Strandstrom, L. 1968. Pituitary adrenal function in patients given long-term adrenal steroid treatment. Acta Endocrinol. 59, 76.
Jasani, M. K., Boyal, J. A., Greig, W. R., Dalakos, T. G., Browning, M. C. K., Thompson, A. and Buchanan, W. W. 1967. Corticosteroid induced suppression of the hypothalamic-pituitary-adrenal axis: observation on patients given oral corticosteroids for rheumatoid arthritis. Quart. J. Med. 36, 261.
Jeffries, W. McK. 1967. Low dose glucocorticoid therapy. Arch. Intern. Med. 119, 265.
Jones, M. T., Brush, F. R. and Neame, R. L. B. 1972. Characteristics of fast feedback control of corticotrophin release by corticosteroids. J. Endocrinol. 55, 489.
Kendall, J. W., Matsuda, K., Duyck, C. and Greer, M. A. 1963. Neural control of ACTH secretion: effect of acute decrebration in the rat. Endocrinology, 72, 845.
Lambe, R. F., Tormey, P. D. and Darragh, A. 1971. The early detection of luteal activity. Irish J. Med. Sci. 140, 316.
Livanou, T., Ferriman, D. and James, V. H. T. 1967. Recovery of hypothalamo-pituitary-adrenal function after corticosteroid therapy. Lancet ii, 856
Mangili, G., Motta, M. and Mortini, L. 1966. In Neuroendocrinology, vol. I, ed. by L. Martini and and W. F. Ganong New York, Academic Press, p. 297.
Meikle, A. W., Lagerquist, L. G. and Tyler, F. H. 1973. A plasma dexamethasone radioimmunoassay. Steroids, 22, 193.
M.R.C. Committee on Clinical Endocrinology, Memorandum. 1963. Determination of 17-oxosteroids in urine. Lancet i, 1415.
Murphy, B. E. P. 1967. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding assay. J. Clin. Endocrinol. 27, 973.
Nishida, S., Matsumara, S., Horino, M., Oyama, H. and Atusko, T. 1976. Single-dose 4 hour dexamethasone suppression test in normal men and its application for the diagnosis of Cushings syndrome. Steroids, 28, 411.
Odell, W. D., Wilber, J. F. and Paul, W. E. 1965. Radioimmunoassay of thyrotropin in human serum. J. Clin. Endocrinol. Metab. 25, 1179.
Ortega, E., Burdick, K. H. and Segre, E. J. 1975. Adrenal suppression by clobetasol propionate. Lancet ii, 1200
Otsuki, M., Dakoda, M. and Baba, S. 1973. Influence of glucocorticoids on TRF-induced TSH response in man. J. Clin. Endocrinol. Metab. 36, 95.
Paris, J. 1961. Pituitary-adrenal suppression after protracted administration of adrenal cortical hormones. Proc. Mayo Clin. 36, 305.
Robinson, B. H. B., Mattingly, D. and Cope, C. L. 1962. Adrenal function after prolonged corticosteroid therapy. Brit. Med. J. i, 1579.
Rodbard, D. and Lewald, J. E. 1970. Computer analysis of radioligand assay and radioimmunoassay data. Acta Endocrinol. Suppl. 147, 79.
Rosner, J. M., Cos, J. J., Biglieri, E. G., Hane, S. and Forsham, P. H. 1963. Determination of urinary unconjugated cortisol by glass fibre chromatography in the diagnosis of Cushing's syndrome. J. Clin. Endocrinol. 23, 820.
Smelik, P. G. 1969. The regulation of ACTH secretion. Acta Physiol. Pharmacol. Neerl. 15, 123.
Straughton, R. C. D. and August, P. J. 1975. Cushing's syndrome and pituitary-adrenal suppression due to clobetasol proprionate. Brit. Med. J. ii, 419.
Taaffe, W. P., O'Kelly, D. A. and Darragh, A. 1975. Simple inexpensive procedure for the measurement of serum thyroxine. Clin. Chim. Acta. 60, 263.
Tan, R. S. H. and Samman, P. D. 1974. Pustular psoriasis with adrenal suppression following topical corticosteroids. Proc. Roy. Soc. Med. 67, 8.
Vigneri, R., Pezzino, V., Filetti, S., Squatrito, S., Galbiati, A. and Polosa, P. 1975. Effect of dexamethasone on thyroid hormone response to TSH. Metabolism, 24, 1209.
Watanabe, H. 1975. Dexamethasone-binding receptor in bovine pituitary cytosol. J. Steroid Biochem. 6, 27.
Woolf, P. D., Gonzales-Barcena, D., Schalch, D. S., Lee, L. A., Arzac, J. P., Schally, A. Y. and Kastin, A. J. 1973. Lack of effect of steroids on thyrotrophin releasing hormone (TRH) mediated thyrotrophin (TSH) release in man. Neuroendocrinology, 13, 56.
Yates, F. E. 1967. In “The Adrenal Cortex” ed. by A. B. Eisenstein. London, J. and A. Churchill Ltd. p. 133.
Zimmermann, E. and Critchlow, V. 1972. Shortlatency suppression of pituitary-adrenal function with physiological plasma levels of corticosterone in the female rat. Neuroendocrinology, 9, 235.
About this article
Cite this article
Lambe, R.F., O'Kelly, D.A. & Darragh, A. Pituitary-adrenal and pituitary-thyroid function during administration of difluocortolone and dexamethasone to human subjects. I.J.M.S. 147, 15 (1978). https://doi.org/10.1007/BF02939362
- Thyroid Stimulate Hormone
- Plasma Cortisol
- IRISH Journal