Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Acute pancreatitis in a patient treated for alcoholic hepatitis

The hypothesis of supranormal ecbolic stimulation of the pancreon

  • 15 Accesses


A 33-yr-old white woman treated for alcoholic hepatitis developed acute pancreatitis during her hospital stay. At autopsy, two major pathological processes were found: alcoholic cirrhosis and chronic pancreatitis. In both, there was evidence of an acute episode, i.e., acute alcoholic hepatitis and acute hemorrhagic pancreatitis superimposed on the chronic alcoholic lesions. The sequence of events would indicate that the acute pancreatic pathology was precipitated by supranormal ecbolic stimulation of the acinar segment of the “pancreon” units, triggered as a result of a high protein and fat diet.

This is a preview of subscription content, log in to check access.


  1. 1

    Tiscornia OM and Dreiling DA. Physiopathogenic hypothesis of alcoholic supranormal ecbolic Stimulation of “pancreon” units secondary to the loss of the negative component of pancreas innervation. The Pancreas 1987 (in press).

  2. 2

    Tiscornia OM, Dreiling DA, Vaccaro MI, Negri G, Celener D, Calvo EL, Cresta MA, and Perec CJ. Hipotesis fisiopatogenica de 1a pancreatitis alcoholica. Excitacion ecbolica supranormal del “Pancreon” secundaria a 1a peridida del componente negativo de 1a inervacion pancreatica. Medicine (Buenos Aires) 1986; 46: 616–624.

  3. 3

    Tiscornia OM, Celener D, Perec CJ, Lehmann ES de, Cresta MA, and Dreiling DA. Physiopathogenic basis of alcoholic pancreatitis: The effects of elevated cholinergic tone and increased “pancreon” ecbolic response to CCK-Pz. Mt Sinai J Med 1983; 50: 369–387.

  4. 4

    Tiscornia OM, Perec CJ, Cresta MA, Tumilasci OR, Lehmann ES de, and Dreiling DA. The relationship of hyperactivity of the duodenal autonomic nervous brain and enhanced “pancreon” secretory response to CCK-Pz in chronic alcoholism. Mt Sinai J of Med 1984; 51: 650–663.

  5. 5

    Tiscornia OM and Sarles H. Evidences for duodeno-pancreatic reflexes and an anti-CCK factor with lidocaine infused intravenously and sprayed topically on pancreatic papilla in non-alcoholic and alcohol-fed dogs. Am J of Gastroenterol 1976; 66: 221–240.

  6. 6

    Tiscornia OM and Dreiling DA. Does the pancreatic gland regenerate? Gastroenerology 1966; 51: 267–271 (editorial).

  7. 7

    Dreiling DA, Bordalo O, Noronha M and Greenstein R. Big duct, little duct or toxic metabolic pathogenesis of pancreatitis. Am J Gastroenterol 1979; 71: 424–426.

  8. 8

    Dreiling DA, Greenstein AJ and Bordalo O. The hypersecretory states of the pancreas. Implications in the pathophysiology of pancreatic inflammation and the pathogenesis of peptic ulcer diathesis. Am J Gastroenterol 1982; 77: 817–820.

  9. 9

    Gallagher S, Hariharan S, and Williams JA. Mechanism of scorpion toxin-induced enzyme secretion in rat pancreas. Gastroenterology 1981; 80: 970–973.

  10. 10

    Adler G and Kern HF. Acute pancreatitis after supranormal cholinergic stimulation. Newsletter 1980; 5: 9 (abstract).

  11. 11

    Dressel TD, Goodale RL, Ameson MA, and Borner JW. Pancreatitis as a complication of anticholinesterase insecticide intoxication. Ann Surg 1979; 189: 199–204.

  12. 12

    Lampel M and Kern HF. Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchow Arch A Pathol Anat Histol 1977; 373: 97–117.

  13. 13

    Watanabe O, Baccino FM, Steer ML, and Meldolesi J. Supranormal Cerulein stimulation and ultrastructure of rat pancreatic acinar cell: Early morphological changes during development of experimental pancreatitis. Amer J Physiol 1984; 246: G457-G467.

  14. 14

    Kano T, Matsumoto T, Mort M, Oyamada M and Nevalainen T. Secretin prevents hyporeactive and morphological responses of rat pancreatic acinar cells to stimulation with supraoptimal concentration of cholecystokinin-octapeptide. Biomedical Research 1984; 5: 355–370.

  15. 15

    Renner IG and Wisner JR. Protective effects of exogenous secretin on ceruletide-induced acute pancreatitis in the rat. J Clin Invest 1983; 72: 1081–1092.

  16. 16

    Bretholz A, Levesque D, Voirol M, Tiscornia OM, Bloom JR, and Sarles H. Impaired secretin release in chronic alcoholic dogs. Digestion 1978; 17: 437–440.

Download references

Author information

Correspondence to P. G. Tiscornia-Wasserman or O. M. Tiscornia or B. J. Rybak or D. A. Dreiling.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tiscornia-Wasserman, P.G., Tiscornia, O.M., Rybak, B.J. et al. Acute pancreatitis in a patient treated for alcoholic hepatitis. Int J Pancreatol. 4, 345 (1989). https://doi.org/10.1007/BF02938469

Download citation

Key Words

  • Alcoholic hepatitis
  • acute pancreatitis
  • supranormal ecbolic
  • stimulation
  • pancreon