Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Serum cholesterol and HDL cholesterol in childhood

  • 11 Accesses


Serum concentrations of total cholesterol and of HDL cholesterol have been measured in 170 Irish children, aged 1–12 years, attending hospital for conditions other than hyperlipidaemia. There were no significant differences between the sexes, or between fasting and non-fasting samples for either estimation. Concentrations of total cholesterol were estimated using a specific enzyme assay and gave a mean value of 3.8 mmol/L±0.8 (one S.D.) (146 mg/100 ml±30). These values are less than those reported in adults using the same method. There was no variation with age. In contrast, sedum concentration of HDL cholesterol increased with age (1.01 mmol/L±0.04 X age in years) (40 mg/100 ml+1.7 X age in years), r=0.4; reaching adult values at the age of 7 years. These data provide background information for studies of lipid disorders in children.

This is a preview of subscription content, log in to check access.


  1. Allain, C. C., Poon, L. S., Chan, C. S. G., Richmond, W. and Fu, P. C. 1974. Enzymatic determination of total serum cholesterol. Clin. Chem. 20, 470.

  2. Berenson, A. S., Srinavasan, S. R., Frerichs, R. R. and Webber, L. S. 1979. Serum high density and its relationship to cardiovascular disease risk factor variables in children—The Bogalusa Heart Study. Lipids 14, 1, 91.

  3. Burnstein, M. and Scholnick, M. R. 1973. Lipoprotein-polyanion-metal interactions. Adv. Lipid. Rest. 11, 65.

  4. Darmody, J. M., Fosbrooke, A. S. and Lloyd, J. K. 1972. Prospective study of serum cholesterol levels during the first year of life. Brit. Med. J. 2, 685.

  5. de Groot, I., Morrison, J. A., Kelly, K. A. 1977. Lipids in school children 6–17 yearss of age. Upper normal limits. Paediatrcs 60, 4, 437.

  6. Fredrickson, D. S., Levy, R. I. and Lees, R. S. 1967. Fat transport in lipoproteins—an integrated approach to mechanisms and disorders. N. Engl. J. Med. 276, 3, 148.

  7. Frerichs, R. R., Srinivasan, S. R., Webber, L. S., Berenson, G. S. 1976. Serum cholesterol and triglyceride levels in 3,466 children from a biracial community. Circulation 54, 2, 302.

  8. Haeckel, R., Sonntag, O., Kulpmann, W. R., Feldmann, V. 1979. Comparison of 9 methods for the determination of cholesterol. J. Clin. Chem. Clin-Biochem. 17, 553.

  9. Krauss, R. M., Lindgreen, F. T., Wingerd, J., Bradley, J. J. and Ramcharan, S. 1979. Effects of oestrogen and progestin on high density lipids. Lipids 14, 113.

  10. Leonard, J. V., Fosbrooke, A. S., Lloyd, J. K. and Wolff, O. H. 1976. Screening for familial hyper-B-lipoproteinemia in children in hospital. Arch. Dis. Child. 51, 842.

  11. Lewis, B. 1076. The Hyperlipidemias 1st Edition. Blackwell Scientific Publications. Oxford.

  12. Miller, A. J. and Miller, N. E. 1975. Plasma high density-lipoprotein concentration and development of ischaemic heart disease. Lancet i, 16.

  13. Morrison, J. A., deGroot, I., Edwards, B. K. 1977. Plasma cholesterol and triglyceride levels in 6,775 school children, ages 6–17. Metabolism 26, 1199.

  14. Morrison, J. A., deGroot, I., Edwards, B. K. 1978. Lipids and lipoproteins in 927 school children, aged 6–17 years. Paediatrics 62 (6), 990.

  15. Morrison, J. A., Laskarzewski, P. M., Rann, J. L., Brookman, R. 1979. Lipids, lipoproteins and sexual maturation during adolescence. The Princeton Maturation Study Metabolism 28. No. 6, 641.

  16. Myos, O. D., Thell, D. S., Forde, O. H. and Vik Mo, H. 1977. Family study of high density lipoproteins cholesterol and the relation to age and sex. Acta Med. Scand. 210, 323.

  17. Orchard, T. J., Rodgers, M., Hedley, A. J. and Mitchell, J. R. A. 1980. Changes in blood lipids and blood pressures during adolescence. Brit. Med. J. 180, 1563.

  18. Stack, J. 1969. Risks of ischaemic heart disease in familial hyperlipoproteinaemic states. Lancet ii, 1380.

  19. Streja, D., Steiner, G., Kwiterovich, P. L. 1978. Plasma high-density lipoproteins and ischaemic heart disease. Ann. Int. Med. 89, 871.

  20. Williams, P., Robinson, D., Bailey, A. 1979. High density lipoprotein and coronary risk factors in normal men. Lancet i, 72.

Download references

Author information

Correspondence to D. A. Kelly.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kelly, D.A., Hooey, H., Neale, G. et al. Serum cholesterol and HDL cholesterol in childhood. I.J.M.S. 150, 213 (1981). https://doi.org/10.1007/BF02938238

Download citation


  • Cholesterol
  • Serum Cholesterol
  • Familial Hypercholesterolaemia
  • Secondary Sexual Characteristic
  • Irish Child