Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Prognostic factors in childhood acute lymphoblastic leukaemia

  • 12 Accesses

  • 2 Citations


58 patients under the age of 14 years with acute lymphoblastic leukaemia were managed from 1971 to 1985. We analysed their overall survival from diagnosis to assess the prognostic significance of clinical and laboratory features presentatdiagnosis. Factors which were statistically significant included white blood count, platelet count, palpable lymph node enlargement, mediastinal widening on chest x-ray and palpable splenic enlargement The purpose of this study was to identify that subset of patients which might have benefitted from more intensive treatment.

This is a preview of subscription content, log in to check access.


  1. 1.

    Fennelly, J. J., O’Donoghue, S., Kavanagh, T. et al. Management of childhood acute leukaemia. Journal of the Irish Medical Association. 1974: 67, 589–594.

  2. 2.

    Peto, J., Eden, O. B., Liffeyman, J. et al. Improvement in prognosis for children with acute lymphoblastic leukaemia. Lancet 1986: 408–411.

  3. 3.

    Berlin, Springer-Verlag, Lampert, F., Heinz, G., Langerman, H-J. et al. Acute lymphoblastic leukaemia: Current status of therapy in children. Recent results in cancer research. Vol. 93, 1984.

  4. 4.

    Peto, R., Pike, M. C., Armitage, P. et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. British J. Cancer. 1977.

  5. 5.

    Crist, W., Pullen, J., Boyett, J. et al. Acute lymphoid leukaemia in adolescents: Clinical and biologic features predict a poor prognosis — a pediatric oncology groups study. Journal Clinical Oncology 1988: 6, 34–43.

  6. 6.

    Blacklock, H., Matthews, J., Buchanan, J. et al. Improving survival poor acute lymphoblastic leukaemia in adolescents and adults. Cancer 1981: 48, 1931–1935.

  7. 7.

    Amadori, S., Meloni, G., Baccarani, M. et al. Long term survival in adolescent and adult acute lymphoblastic leukaemia. Cancer 1983: 52, 30–34.

  8. 8.

    Jacobs, A. D., Gale, R. P. Recent advances in the holugy and treatment of acute lymphoblastic leukaemia in adults. N., England Medical Journal 1984: 311, 1219–1231.

  9. 9.

    Crist, W., Pullen, J., Boyett, J. et al. Clinical and biologic features predict a poor prognosis in acute lymphoid leukaemia in infants. A pediatric oncology group study. Blood 1986: 67, 135–140.

  10. 10.

    Simonem J. J., Verzosa, M. S., Rudy, A. J. et al. Initial features and prognosis in 383 children with acute lymphocytic leukaemia. Cancer 1975: 36, 2099–2108.

  11. 11.

    Miller, R.D., Leikin, S., Albo, V. et al. Prognostic factors and therapy in acute lymphoblastic leukaemia of childhood. CCG-141. Cancer 1983: 51, 1041–1049.

  12. 12.

    Raotanen, J., Simens, M. A. Elevated serum transaminase activity at diagnosis is associated with rapidly progression disease in children with acute lymphoblastic leuk-aema. Cancer 1988: 61, 754–757.

  13. 13.

    Piu, C-H., Dodge, R. K., Dahl, G. V. et al. Serum lactic dehydrogenase level has prognostic value in childhood acute lymphoblastic leukaemia. Blood, Vol 66, No. 4, October 85, pp. 778–782.

  14. 14.

    Fliedner, V. Von. Contribution of immunological markers to the diagnosis and prognosis of human leukaemia. Eur. J. Cancer Clin Oncol. 1984: Vol. 21, No. 3, 347–353.

  15. 15.

    Sather, H., Miller, D., Besbit, M. et al. Differences in prognosis for boys and girls with acute lymphoblastic leukaemia. The Lancet 1981: 1, 739–43.

  16. 16.

    Motts, M. J. Baumer. Sex and prognosis in childhood acute leukaemia. Lancet 1978: ii, 128–129.

  17. 17.

    Motts, J. Baumer, Gentle, T. Sex and prognosis in childhood acute lymphocytic leukaemia. Lancet 1978: ii, 673.

  18. 18.

    Robinson, I., Sather, H., Coecia, P. et al. Assessment of the interrelationship of prognostic factors in childhood acute lymphocytic leukaemia. Amer. J. Ped. Hem. Oncol. 1980: 2, 5–13.

  19. 19.

    Acute lymphocytic leukaemia. U.K. Leukaemia Research Trials for Children and Adults. London: Leukemia Research Fund 1987: 20–32. Kay, H.

  20. 20.

    George, S., Fembach, D., Vietti, T. et al. Factors influencing survival in paediatric acute leukaemia. Cancer 1973: 32, 1542–53.

  21. 21.

    Evans, D., Morris-Jones, P., Hann, I. et al. Sex and prognosis in childhood acute lymphoctic leukaemia. Lancet 1978: ii, 522–523.

  22. 22.

    Revesz, T., Kavdos, G., Kajtar, P. et al. The prognostic significance of bone and joint manifestations in childhood leukaemia. Journal Rheum. 1982: 3, 647–648.

  23. 23.

    Costello, P. B., Breacher, M. L., Starr, J. C. et al. A prospective analysis of the frequency, course and possible prognostic significance of the joint manifestations of childhood leukaemia. Journal Rheumatol. 1983: 10, 753–757.

  24. 24.

    Schaller, J. Arthritis as a presenting manifestation of malignancy in children. J. Paediatric 1972: 81, 793–797.

  25. 25.

    Walters, T. R., Buchare, M., Simona, J. et al. Poor prognosis in negro children with acute lymphoblaslic leukaemia. Cancer 1972: 29, 210–214.

  26. 26.

    Hicosonmcz, G., Ozsoylu, S., Yetgin, S. et al. Poor prognosis of childhood acute lymphoblastic leukaemia. British Medical Journal 1983: 286, 1437.

  27. 27.

    Michael, P. M., Garson, O. M., Ekert, H., Tauro, G., Rennis, G. C. and Pilkington, G. P. Prospective study of childhood acute lymphocytic leukaemia: Haemologic, immunologic and cytogeneticcorrelations. Medical and Paediatric Oncology. 1988: 16153–161.

  28. 28.

    Le Beau, M. M., Rowley, J. D. Recurring chromosomal abnormalities in leukaemia and lymphoma. pp. 371–394. Cancer Surveys, Vol 3, No. 3, 1984.

  29. 29.

    Seeker-Walker, L.M., Sylvia, D., Tawler, R. M. Hardisty. Prognostic implications of chrosomal findings in acute lymphoblastic leukaemia at diagnosis. Brirish Medical Journal 1978: 2, 1529–1530.

  30. 30.

    Seeker-Walker, L. M., Swansbury, G. J., Hardisty, R. M. et al. Cytogenetics of acute lymphoblastic leukaemia in children as a factor in the prediction of long-term survival. Br. J. Haematol. 1982: 52, 389–399.

  31. 31.

    Williams, D. L., Raimondi, S., Riveria, G. et al. Presence of clonal chrosome abnornmalities in virtually all cases of acute lymphoblastic leukaemia. N. Eng. J. Med. 1985: 313, 640–641.

  32. 32.

    Williams, D. L., Harber, J., Murphy, S. B. et al. Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukaemia blood. 1986: 68, 205–212.

  33. 33.

    Third International Workshop on Chrosomes in Leukaemia, 1981.

  34. 34.

    Bloomfield, C. D., Brunning, R. D., Smith, K. A. et al. Cancer genetics and cytogenetics 1, 229–238

  35. 35.

    Therapeutic manoeuvres and the prolongation of remission in childhood acute lymphocytic leukaemia with poor prognostic factors. Preliminary report - S.W.O.G. Study 7420. Abstract 767. Proc. A.A.C.R. 1979: 20, 190.

  36. 36.

    Moe, P. G., Siep, M., Finn, P. H. et al. Intermediate dose methotrexate (I.D.M.) in childhood acute lynmphocytic leukaemia in Norway. Acta Paediatric Scand. 1981: 70, 73–79.

  37. 37.

    Gaynor, P. S., Bleyer, W. A., Steinherg, P. G. et al. Modified BFM therapy for children with previously untreated acute lymphoblastic leukaemia and unfavourable prognostic features. The American Journal of Paediatric Haematology/Oncology. 1988: 10(1), 42–50.

Download references

Author information

Correspondence to J. Armstrong or M. Pomeroy or J. J. Fennelly or S. Cahalane.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Armstrong, J., Pomeroy, M., Fennelly, J.J. et al. Prognostic factors in childhood acute lymphoblastic leukaemia. I.J.M.S. 159, 40–43 (1990). https://doi.org/10.1007/BF02937246

Download citation


  • Acute Lymphoblastic Leukaemia
  • White Cell Count
  • Acute Lymphoid Leukaemia
  • Acute Lymphocytic Leukaemia
  • Mediastinal Widening