A case of autoimmune chronic active hepatitis (C.A.H.) in a 12-year old Down Syndrome child is described. This represents the second only documented case of autoimmune C.A.H. occurring in Down Syndrome; the first well-described case1 died from the disease. The patient described below had a satisfactory response to steroid therapy with restoration of normal liver histological appearances and function despite severe disease at presentation. Chronic hepatitis in Down Syndrome, although more usually of hepatitis B viral aetiology, may also be autoimune in nature and resolve satisfactorily with appropriate therapy.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
McCulloch, A. J., Ince., P. G., Kendall-Taylor, P. Autoimmune chronic active hepatitis in Down Syndrome. J. Med. Genet. 1982: 19 (3): 232–234.
Szmuness, W., Prince, A. M. The epidemiology of serum hepatitis (SH) infections — a controlled study in two closed institutions. Am. J. Epidemiol. 1971: 94: 585–595.
Chaudhary, R. K., Perry, E., Cleary, T. E. Prevalence of hepatitis B infection among residents of an institution for the mentally handicapped. A. J. Epidemiol. 1977: 105: 123–126.
Whittingham, S., Sharma, D. L. B., Pitt, D. B., Mackay, I. R. Stress deficiency of the T-lymphocyte system exemplified by Down Syndrome. Lancet 1977: i, 163–166.
Burgio, G. R., Ugazio, A. G., Nespoli, L. et al. Derangements of immunoglobulin levels, phytohemagglutinin responsiveness and T and B cell markers in Down Syndrome at different ages. Eur. J. Immun. 1975: 5, Pt. 9: 600–603.
Ugazio, A. G., Maccario, R., Duse, M., Burgio, G. R. T-lymphocyte deficiency in Down Syndrome. Lancet 1977: i: 1062.
About this article
Cite this article
O’Mahony, D., Whelton, M.J. & Hogan, J. Down syndrome and autoimmune chronic active hepatitis: Satisfactory outcome with therapy. I.J.M.S. 159, 21 (1990). https://doi.org/10.1007/BF02937210
- Chronic Hepatitis
- Down Syndrome
- Chronic Active Hepatitis
- Alopecia Areata