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Prenatal development of cutaneous afferent connections in the spinal cord of fetal sheep

A physiological and neurochemical study

Abstract

In this study we have examined the shysiological and neurochemical development of the cutaneous afferent pathways from the hindlimb to the spinal cord in fetal sheep. We have shown that somatosensory input from the hindlimb evokes activity in DRG neurons at 87d gestation and in cells in the dorsal horn at 92d (term, 146d). There is evidence of immunoreactivity for substance P, calcitonin gene-related peptide and glutamine several days prior to this at 77–80 days. The implication of these findings are discussed.

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References

  1. Duggan A. W., Hendry I. A., Morton C. R., Hutchinson W. D., and Zhao Z. Q. (1988) Cutaneous stimuli release immunoreactive substance P in the dorsal horn of the cat.Brain Res. 451, 261–273.

  2. Fitzgerald M. (1991) A physiological study of the prenatal development of cutaneous sensory input to dorsal hom cells in the rat.J. Physiol. 432, 473–482.

  3. Morton C. R. and Hutchinson W. D. (1989) Release of sensory neuropeptides in the spinal cord: studies with calcitonin gene-related peptide and galanin.Neuroscience 31(3), 807–815.

  4. New H. V. and Mudge A. W. (1986) Calcitonin generelated peptide regulates muscle acetylcholine receptor synthesis.Nature 323, 809–811.

  5. Shatz C. and Stryker M. P. (1988) Prenatal tetrodotoxin infusion blocks segregation of retino-geniculate afferents.Science 242, 87–89.

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Author information

Correspondence to Sandra Rees.

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Rees, S., Rawson, J. & Nitsos, I. Prenatal development of cutaneous afferent connections in the spinal cord of fetal sheep. Mol Neurobiol 5, 247–249 (1991). https://doi.org/10.1007/BF02935549

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Index Entries

  • Prenatal
  • development
  • cutaneous
  • sensory
  • spinal cord
  • synaptic connections