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Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice

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Abstract

Objective: In order to study the effects of Chinese Kidney-tonifying (KT) herbal medicine on the M-cholinergic receptor(M-R) and the acetylcholinesterase(AchE) activity in the models’ cerebral cortex.Methods: Dementia mimetic mice models were formed with aluminum chloride.Results: The Muscarine receptor total receptor concentration (M-Rt) lowered and the AchE increased in the model significantly compared with healthy young mice. KT could markedly reduce the increase of AchE and elevate the lowered M-Rt in cerebral cortex of the dementia mimetic mice and improve the memory.Conclusions: KT is effective in preventing the degeneration of cerebral function and presenile dementia.

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References

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    Heny I. Yanmamura. Neurotransmitter receptor binding. New York: Raven Press 1978:57–91.

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Author information

Correspondence to Qi-Zhong Mo or Jun Ma or Bin Gong or Lian Ning or Bao-Mei Wang.

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Mo, Q., Ma, J., Gong, B. et al. Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice. CJIM 3, 127–130 (1997). https://doi.org/10.1007/BF02935371

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Key Words

  • Kidney-tonifying
  • dementia mimetic
  • acetylcholinesterase
  • M-cholinergic receptor