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A clinical study in epidural injection with lappaconitine compound for post-operative analgesia

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Abstract

Objective: The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed.Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22.5 mg of bupivacaine, was used for the observed group, and lappaconitine 12 mg, bupivacaine 22.5 mg and morphine 2 mg for the control group respectively, All were given by epidural injection with single blind method during post-operative pain of incision operation.Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D, and the efficacy was morphine group > LB > bupivacaine > lappaconitine. There was significant difference between group A and B in the above two parameters,P < 0.01 andP < 0.05. The analgesia maintenance time of a single injection was morphine >LB> lappaconitine> bupivacaine, that of group D was significantly longer than that of group A (P < 0.01).Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides, it had no side-effect and safer than morphine.

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Author information

Correspondence to Min-guang Chen or Qi-hao Wang or Wei Lin or Yu-bing Lin or Kong-li Chen or Fei Liu or Qin Lin or Hua-yang Lin or Hong-da Cai.

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Chen, M., Wang, Q., Lin, W. et al. A clinical study in epidural injection with lappaconitine compound for post-operative analgesia. CJIM 3, 257–260 (1997). https://doi.org/10.1007/BF02934824

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Key Words

  • lappaconitine compound
  • bupivacaine
  • morphine
  • epidural injection
  • post-operative analgesia