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Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action

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Abstract

Dynamic observations for 4 weeks were made on left ventricular function and oxygen free radicals (OFR) in 43 patients who suffered the first attack of acute myocardial infarction and was hospitalized in Coronary Care Unit within 36 hours. The results showed that Radix Astragali (RA) could strenthen the left ventricular function and had an effect of scavenging OFR. After administration of RA, the ratio of pre-ejection period/left ventricular ejection time (PEP/LVET) was decreased, the superoxide dismutase (SOD) activities of erythrocytes were increased, and the lipid peroxidation (LPO) concentration of plasma was reduced. There was a significant difference between the RA group and the control group in the parameters mentioned above. The study demonstrated that the PEP/LVET ratio was closely correlated with SOD and LPO. It suggested that the scavenging effect of RA on OFR was one of its mechanisms of cardiotonic action.

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Author information

Correspondence to Li-Xin Chen or Jia-Zhen Liao or Wei-Qin Guo or Wei-Jie Yu or La-Mei Qin.

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Chen, L., Liao, J., Guo, W. et al. Effects of Radix Astragali on left ventricular function and oxygen free radicals in acute myocardial infarction patients and its mechanism of cardiotonic action. CJIM 2, 252–254 (1996). https://doi.org/10.1007/BF02934686

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Key Words

  • Radix Astragali
  • acute myocardial infarction
  • pre-ejection period/left ventricular ejection time
  • superoxide dismutase
  • lipid peroxidation