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Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro

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Abstract

Qiwei Baizhu San was found to have an inhibitory effect on human rotavirus at monolayers of MA104 cells. A 50% reduction in plaque number, a 101.86 TCID50 decrease in viral replication index and an around 60% inhibition in viral RNA synthesis were observed at concentration of 100 mg/ml. Furthermore, the cytotoxicity of the decoction was low, while its promoting effect on growth and proliferation of the culture cells was observed at the concentrations of 12.5~50 mg/ml. The decoction was also found to have effects in prolonging the survival time of infected cells with rotavirus and promoting the regeneration of the infected cells.

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References

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    WHO Scientific Working Group. Rotavirus and otherviral diarrheas. Bull WHO 1980; 58: 183 - 198.

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    Vaughan VC. Nelson’s text book of pediatrics, ed 11. Philadelphia: Saunders, 1979: 1072 - 1075.

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    Sato K, Ihaba Y, Shinzuka T, et al. Isolation ofhuman ro-tavirua in cell cultures. Arch Virol 1981; 69: 155 - 160.

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Author information

Correspondence to Shuang-Teng He or Fei-Zhou He or Shun-Xiang Li or Shan Wang or Can-Rong Wu or Zheng-Wu Ou.

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He, S., He, F., Li, S. et al. Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro. CJIM 2, 68–71 (1996). https://doi.org/10.1007/BF02934232

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Key Words

  • Human rotavirus
  • Qiwei Baizhu San
  • tissue culture
  • antiviral activity