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Regression of atypical lymphoid hyperplasia after eradication ofHelicobacter pylori

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Abstract

A rare case of endescopic and histological regression of a gastric lymphoid mucosal lesion after eradication ofHelicobacter pylori is reported. A 72-year-old man was suspected of having a low-grade B-cell gastric mucosa-associated lymphoid tissue (MALT) lymphoma by endoscopic and histological findings. Histology of biopsy specimens showed massive infiltration of atypical lymphocytes and lymphoepithelial lesions. Immunohistochemical staining revealed kappa light chain expression in the infiltrated atypical lymphocytes to be twofold that of lambda light chain. The above diagnosis was thus highly suspected but not confirmed. Antibiotic therapy was given on the basis of evidence ofH. pylori infection. Successful eradication ofH. pylori resulted in remarkable improvement of endoscopic and histological findings. Follow-up studies were carried out 8 months after eradication, with no evidence of relapse. The eradication ofH. pylori appears to be an effective alternative therapy for B-cell lymphoproliferative disease, although longer follow-up and further studies are needed before this treatment can be establisted.

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References

  1. 1.

    Isaacson PG, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue, a distinctive type of B-cell lymphoma. Cancer 1983;52:1410–1416.

  2. 2.

    Isaacson PG, Wright DH. Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer 1984;53:2515–2524.

  3. 3.

    Isaacson PG, Spencer J. Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology 1987;11:445–462.

  4. 4.

    Wotherspoon AC, Ortiz-Hidalgo C, Isaacson PG.Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175–1176.

  5. 5.

    Hussel T, Isaacson PG, Crabtree JE, Spencer J. The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue toHelicobacter pylori. Lancet 1993;342:571–574.

  6. 6.

    Stolte M.Helicobacter pylori gastritis and gastric MALT-lymphoma. Lancet 1992;339:745–746.

  7. 7.

    Wotherspoon AC, Doglioni C, Isaacson PG. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication ofHelicobacter pylori. Lancet 1993;342:575–577.

  8. 8.

    Wotherspoon AC, Doglioni C, Isaacson PG. Antibiotic reatment for low-grade gastric MALT lymphoma. Lancet 1994; 343:1503.

  9. 9.

    Stolte M, Eidt S. Healing gastric MALT lymphomas by eradicatingH. pylori? Lancet 1993;342:568.

  10. 10.

    Bayerdorffer E, Neubauer A, Rudolph B, et al. for MALT Lymphoma Study Group. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure ofHelicobacter pylori infection. Lancet 1995;345:1591–1594.

  11. 11.

    Coglatti SB, Schmid U, Takahashi H. Primary B cell gastric lymphoma: A clinicopathological study of 145 patients. Gastroenterology 1991;101:1159–1170.

  12. 12.

    Takano Y, Kato Y, Sugano H. Histopathological and immunohistochemical study of atypical lymphoid hyperplasia and benign lymphoid hyperplasia of the stomach. Jpn J Cancer Res 1992;83:288–293.

  13. 13.

    Takano Y, Kato Y, Okayasu I. Where should ordinary RLH be placed in relation to ALh, BLH, and gastric MALT lymphoma (in Japanese with English abstract). Endosc Dig 1995;7:1479–1487.

  14. 14.

    Horstmann M, Erttmann R, Winkler K. Relapse, of MALT lymphoma associated withHelicobacter pylori after antibiotic treatment. Lancet 1994;343:1098–1099.

  15. 15.

    Cammarota G, Montalto M, Tursi A, et al.Helicobacter pylori infection and rapid relapse of low-grade B-cell gastric lymphoma. Lancet 1995;345:192.

  16. 16.

    Karita M, Li Q, Okita K. Evaluation of new triple therapy for eradication ofH. pylori infection in nude mouse model. Am J Gastroenterol 1993;88:1366–1372.

  17. 17.

    Fukuda Y, Yamamoto Y, Okui M., et al. Combination therapies with proton pump inhibitor forHelicobacter pylori infected gastric ulcer patients. J Clin Gastroenterol 1995;20(Suppl 2):S132–135.

  18. 18.

    Ono H, et al. Clinicopathological changes of gastric MALT lymphomas with or without eradication ofHelicobacter pylori (in Japanese with English abstract). Stomach Intestine 1996;1:83–92.

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Correspondence to Toshihito Tanahashi.

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Tanahashi, T., Tatsumi, Y., Sawai, N. et al. Regression of atypical lymphoid hyperplasia after eradication ofHelicobacter pylori . J Gastroenterol 32, 543–547 (1997). https://doi.org/10.1007/BF02934097

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Key words

  • Helicobacter pylori
  • atypical lymphoid hyperplasia
  • primary gastric MALT lymphoma