Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Malignant lymphoma of the stomach after chemotherapy for hepatocellular carcinoma

  • 31 Accesses

  • 4 Citations

Abstract

A rare case of malignant lymphoma of the stomach after treatment for hepatocellular carcinoma (HCC) is reported. A 72-year old man presented with a large mass on the right hypochondrium, which was diagnosed as HCC associated with chronic hepatitis C with cirrhosis. The inoperable tumor was treated conservatively with cisplatin, etoposide, carboplatin, and Lipiodol infused into the hepatic artery, together with transcatheter arterial embolization. The patient presented 38 months later with features suggestive of gastric ulceration. Endoscopy and histological examination of biopsy material confirmed the presence of malignant lymphoma of the stomach. He ultimately died as a result of hepatic failure. The clinical presentation suggests that gastric lymphoma was possibly related to the lymphotropic effect of hepatitis C virus (HCV) and exacerbated by intraarterial injection of the cytotoxic drugs.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Munoz N, Linsell A. Epidemiology of Primary liver cancer. In: Correa P, Haenszel W (eds) Epidemiology of Cancer of the digestive tract. Hague: Martinus Nijhoff, 1982;161–195.

  2. 2.

    Lin D-Y, Liaw Y-F, Wu C-S, et al. Hepatocellular carcinoma associated with second primary malignancy. Liver 1987;7:106–109.

  3. 3.

    Takayasu K, Kasugai H, Ikeya S, et al. A clinical and radiologic study of primary liver cancer associated with extrahepatic primary cancer. Cancer 1992;69:45–51.

  4. 4.

    Talamo TS, Dekker A, Gurecki J, et al. Primary hepatic malignant lymphoma: Its occurrence in a patient with chronic active hepatitis, cirrhosis, and hepatocellular carcinoma associated with hepatitis B viral infection. Cancer 1980;46:336–339.

  5. 5.

    Ikura Y, Nagatomi N, Ohtani K, et al. Autopsy case of hepatocellular carcinoma associated with lupoid hepatitis and complicated by malignant lymphoma. Gastroenterol Jpn 1993;28:564–569.

  6. 6.

    Di Stasi M, Sbolli G, Fornari F, et al. Extrahepatic primary malignant neoplasms associated with hepatocellular carcinoma: High occurrence of B cell tumors. Oncology 1994;51:459–464.

  7. 7.

    Ferri C, La Civita L, Caracciolo F, et al. Non-Hodgkin's lymphoma: Possible role of hepatitis C virus. JAMA 1994; 272:355–356.

  8. 8.

    Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 1994;84:1361–1392.

  9. 9.

    Lombardo L, Rota Scalabrini D, Vineis P, et al. Malignant lymphoproliferative disorders in liver cirrhosis. Ann Oncol 1993;4:245–250.

  10. 10.

    Silvestri F, Pipan C, Barillari G, et al. Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders. Blood 1996;87:4296–4301.

  11. 11.

    Ferri C, La Civita L, Monti M, et al. Chronic hepatitis C and B-cell non-Hodgkin's lymphoma. Q J Med 1996;89:117–122.

  12. 12.

    Pozzato G, Mazzaro C, Crovatto M, et al. Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. Blood 1994;84:3047–3053.

  13. 13.

    Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, et al.Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 1991;338:1175–1176.

  14. 14.

    Eidt S, Stolte M, Fischer R.Helicobacter pylori gastritis and primary gastric non-Hodgkin's lymphomas. J Clin Pathol 1994;47:436–439.

  15. 15.

    Ansfield FJ, Ramirez G, Skibba JL, et al. Intrahepatic arterial infusion with 5-fluorouracil. Cancer 1971;28:1147–1151.

  16. 16.

    Ramming KP, Sparks FC, Eilber FR, et al. Hepatic artery ligation and 5-fluorouracil infusion for metastatic colon carcinoma and primary hepatoma. Am J Surg 1976;132:236–242.

  17. 17.

    Dusheiko GM, Hobbs KEF, Dick R, et al. Treatment of small hepatocellular carcinomas. Lancet 1992;340:285–288.

  18. 18.

    Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire: A comparison of Lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med 1995;332:1256–1261.

  19. 19.

    Ensminger WD, Gyves JW. Regional cancer chemotherapy. Cancer Treat Rep 1984;68:101–115.

  20. 20.

    Chuang VP, Wallace S, Stroehlein J, et al. Hepatic artery infusion chemotherapy: Gastroduodenal complications. AJR 1981; 137:347–350.

  21. 21.

    Hall DA, Clouse ME, Gramm HF. Gastroduodenal ulceration after hepatic arterial infusion chemotherapy. AJR 1981;136:1216–1218.

  22. 22.

    Colon-Otero G, Malkasian GD, Edmonson JH. Secondary myelodysplasia and acute leukemia following carboplatincontaining combination chemotherapy for ovarian cancer. J Natl Cancer Inst 1993;85:1858–1860.

  23. 23.

    Bassett WB, Weiss RB. Acute leukemia following cisplatin for bladder cancer. J Clin Oncol 1986;4:614.

  24. 24.

    Pogliani EM, Pioltelli P, Rossini F, et al. Acute leukemia following cisplatin for ovarian cancer. Heamatologica 1987;72:184–185.

  25. 25.

    Sprance HE, Hempling RE, Piver MS. Leukemia following cisplatin-based chemotherapy for ovarian carcinoma at Roswell Park. Eur J Gynaec Oncol 1992;13:131–137.

  26. 26.

    Snowden JA, Laidlaw ST, Champion AE, et al. Acute promyelocytic leukaemia after treatment for seminoma with carboplatin. Lancet 1994;344:1361.

  27. 27.

    Zwelling LA, Kohn KW. Effects of cisplatin on DNA and the possible relationships to cytotoxicity and mutagenicity in mammalian cells. In: Prestayko AW, Crooke ST, Carter SK (eds) Cisplatin: current status and new developments. Orlando: Academic, 1980;21–35.

  28. 28.

    Chibber R, Ord MJ. The mutagenic and carcinogenic properties of three second-generation antitumor platinum compounds: A comparison with cisplatin. Eur J Cancer Clin Oncol 1989;25:27–33.

Download references

Author information

Correspondence to Katsuhisa Omagari.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Matsuo, I., Omagari, K., Ikuno, N. et al. Malignant lymphoma of the stomach after chemotherapy for hepatocellular carcinoma. J Gastroenterol 32, 533 (1997). https://doi.org/10.1007/BF02934095

Download citation

Key words

  • hepatocellular carcinoma
  • gastric lymphoma
  • cytotoxic drugs
  • hepatitis C virus