Development of resistance to ivermectinin vitro is reported for the first time. Two strains ofCaenorhabditis elegans D5 and D6 able to grow on agar plates after treating with up to 3 mg ivermectin per L were selected. The parent strain N2 was extremely sensitive to ivermectin, its growth being inhibited by treatment with 0.1–0.2 mg IVM per L.
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Novák, J., Vaněk, Z. Screening for a new generation of anthelminthic compounds.In vitro selection of the nematodeCaenorhabditis elegans for ivermectin resistance. Folia Microbiol 37, 237–238 (1992). https://doi.org/10.1007/BF02933156
- Parent Strain
- Resistant Strain
- Wild Strain