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Molecular and chemical neuropathology

, Volume 21, Issue 2–3, pp 353–368 | Cite as

Altered RNA turnover in carcinogenesis

The diagnostic potential of modified base excretion
  • Christopher C. Marvel
  • John Del Rowe
  • Eric G. Bremer
  • Joseph R. Moskal
Article

Abstract

Excretion of urinary modified nucleosides is frequently elevated in patients with oncogenic disease. Increases of urinary pseudouridine excretion are now demonstrated in patients with a variety of brain tumors. The potential use of urinary modified base excretion as a cancer marker is discussed and possible sources of the elevated nucleosides are detailed. The specific steps in RNA metabolism that result in increased levels of RNA nucleoside excretion are poorly understood. This knowledge will be necessary to understand the molecular mechanism and the clinical significance of urinary nucleoside excretion in treatment and diagnosis of oncogenic disease.

Index Entries

Urinary nucleosides urinary excretion modified nucleosides tumor markers RNA tRNA pseudouridine 

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Copyright information

© Humana Press Inc. 1994

Authors and Affiliations

  • Christopher C. Marvel
    • 1
  • John Del Rowe
    • 2
  • Eric G. Bremer
    • 3
  • Joseph R. Moskal
    • 3
  1. 1.Department of Radiation Oncology, Southern California Cancer CenterUniversity of Southern CaliforniaLos Angeles
  2. 2.Department of Radiation OncologyMontefiore Medical CenterBronx
  3. 3.Chicago Institute for NeuroSurgery and NeuroResearchChicago

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