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Clinical evaluation of tissue plasminogen activator (t-PA) levels in patients with liver diseases

  • Liver, Pancreas, and Biliary Tract
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

Tissue plasminogen activator (t-PA) levels in plasma or serum were studied in 416 patients with liver diseases: acute hepatitis (AH, n=30); fulminant hepatitis (FH, n=36); chronic inactive hepatitis (CIH, n=57); chronic active hepatitis (CAH, n=39); compensated liver cirrhosis (cLC, n=78); decompensated liver cirrhosis (dLC, n=84); hepatocellular carcinoma (HCC, n=64); advanced hepatocellular carcinoma (aHCC, n=28); and compared with that of a control group (n=106) of healthy subjects. The t-PA levels showed significant increase in patients with AH, FH, CAH, cLC, dLC and HCC, compared with normal controls. The abnormal rates in t-PA levels (higher than 8.3 ng/ml) for each type of liver diseases were 86.1% in FH, 46.2% in CAH, 50% in cLC, 85.7% in dLC, 67.2% in HCC, and 89.3% in aHCC. t-PA levels tended to be higher in more advanced liver diseases. t-PA levels significantly correlated positively with plasminogen activator inhibitor (PAI-1) in AH, cLC, dLC, HCC and aHCC, and negatively with plasmin arplasmin inhibitor complex (PIC), plasminogen (Pig), FDP, AT III and α2-plasmin inhibitor (α2-PI) in dLC, prothrombin time (PT) and fibrinogen (Fbg) in HCC. t-PA levels in patients with FH, CAH and dLC were significantly higher than those in patients with AH, CIH and cLC, respectively. Moreover, the changes of t-PA levels in the clinical courses of various liver diseases revealed that t-PA levels increased sensitively with progression of liver diseases or in advanced liver diseases. These results suggest that t-PA has a potential clinical use to judge the prognosis of liver diseases and is a sensitive marker for severe liver diseases from tjie standpoint of coagulofibrinolysis, especially in relation to PAI-I.

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Authors and Affiliations

  1. Department of Medicine, St. Marianna University School of Medicine, 1197-1 Yasashicho, Asahi-ku, 241, Yokohama, Japan

    Kazuhiko Okabe M.D. & Ikuo Kato

  2. Department of Medicine, Iwate Medical University School of Medicine, Morioka, Japan

    Shunichi Sato & Toshifumi Kashiwabara

  3. Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan

    Seiichi Furuta & Hiroshi Sato

  4. Department of Medicine, Kurume University School of Medicine, Kurume, Japan

    Kyuichi Tanikawa & Ryukichi Kumashiro

  5. Hiratsuka Kyosai Hospital, Hiratsuka, Japan

    Masaaki Kanayama

Authors
  1. Kazuhiko Okabe M.D.
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  2. Ikuo Kato
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  3. Shunichi Sato
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  4. Toshifumi Kashiwabara
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  5. Seiichi Furuta
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  6. Hiroshi Sato
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  7. Kyuichi Tanikawa
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  8. Ryukichi Kumashiro
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  9. Masaaki Kanayama
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Okabe, K., Kato, I., Sato, S. et al. Clinical evaluation of tissue plasminogen activator (t-PA) levels in patients with liver diseases. Gastroenterol Jpn 27, 61–68 (1992). https://doi.org/10.1007/BF02775065

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  • DOI: https://doi.org/10.1007/BF02775065

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