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Skeletal Radiology

, Volume 17, Issue 8, pp 545–550 | Cite as

The radiographic appearances following adequate transfusion in β-thalassaemia

  • Pier Nuccio Scuttellari
  • Carlo Orzincolo
  • Franca Franceschini
  • Bruno Bagni
Articles

Abstract

The main lesions of the skull and hand, observed in a group of hypertransfused β-thalassaemic patients, are compared with a control group of low-transfused patients. Bony abnormalities reflect the relationship between proliferating bone marrow and bone cortex, and hypertransfusion therapy will prevent development of lesions only if established early in life. If this is done, the diploë in the skull may become normal, overgrowth of facial bones is moderate, pneumatisation of the paranasal sinuses is not completely prevented, and the “hair-brush” pattern may disappear completely. A normal appearance of the hand in adequately treated patients differentiates between prepubertal patients and adults.

Key words

Thalassaemia Low transfusion regimen (LTR) Hypertransfusion regimen (HTR) Skeletal lesions Metacarpal bone mass 

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Copyright information

© International Skeletal Society 1989

Authors and Affiliations

  • Pier Nuccio Scuttellari
    • 1
  • Carlo Orzincolo
    • 2
  • Franca Franceschini
    • 3
  • Bruno Bagni
    • 2
  1. 1.Institute of RadiologyUniversity of Ferrara School of MedicineFerraraItaly
  2. 2.Department of RadiologySt. Anna Hospital of FerraraFerraraItaly
  3. 3.Institute of Medical SemeiologyUniversity of Ferrara School of MedicineFerraraItaly

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