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Pharmaceutisch Weekblad

, Volume 5, Issue 5, pp 213–216 | Cite as

201Tl-diethyldithiocarbamate: a possible radiopharmaceutical for brain imaging

  • A. Vyth
  • P. J. Fennema
  • J. B. van der Schoot
Original Articles

Abstract

For estimating regional brain perfusion with a gamma camera lipophilic radiopharmaceuticals are required. This paper describes the development of201Tl-diethyldithiocarbamate (201TlDDC). First the compound NaDDC was tested for stability and an assay was developed. Next the201TlDDC complex was prepared and checked for lipophilicity and stability by paper chromatography. A scintigraphic pilot study using this agent in a rabbit showed considerable brain uptake, compared to201TlCl. Finally we performed a study in rats on the distribution of201TlDDC in different organs. The results confirmed the lipophilicity of the agent. Within the first hour the percentage of injected dose per gram tissue was 2.73% in the cerebrum and 1.35% in the cerebellum. These data are in good agreement with some other agents used for assessment of brain blood flow.

Keywords

Public Health Blood Flow Internal Medicine Pilot Study Regional Brain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1983

Authors and Affiliations

  • A. Vyth
    • 1
  • P. J. Fennema
    • 1
  • J. B. van der Schoot
    • 1
  1. 1.Department of Nuclear MedicineAcademic Hospital of the University of AmsterdamAZ AmsterdamThe Netherlands

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