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Pharmaceutisch Weekblad

, Volume 7, Issue 5, pp 208–211 | Cite as

Synthesis and radioreceptor binding activity of N-0437, a new, extremely potent and selective D2 dopamine receptor agonist

  • A. S. Horn
  • P. Tepper
  • J. Van Der Weide
  • M. Watanabe
  • D. Grigoriadis
  • P. Seeman
Short Communications

Abstract

The synthesis of a new, potent and selective D2 dopamine receptor agonist, N-0437, of the 2-aminotetralin group is described. The results of a radioreceptor binding assay using a homogenate of porcine anterior pituitary as a tissue source for D2 dopamine receptors and3H-spiperone as radioligand demonstrate that this compound is one of the most potent compounds so far evaluated in this test system.

Keywords

Public Health Internal Medicine Dopamine Dopamine Receptor Binding Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1985

Authors and Affiliations

  • A. S. Horn
    • 1
  • P. Tepper
    • 1
  • J. Van Der Weide
    • 1
  • M. Watanabe
    • 2
  • D. Grigoriadis
    • 2
  • P. Seeman
    • 2
  1. 1.Department of PharmacyUniversity of GroningenAW GroningenThe Netherlands
  2. 2.Department of PharmacologyUniversity of TorontoTorontoCanada

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