Pharmaceutisch Weekblad

, Volume 7, Issue 5, pp 194–201 | Cite as

The photochemical decomposition of the progestogenic 19-norsteroid, norethisterone, in aqueous medium

  • A. G. J. Sedee
  • G. M. J. Beijersbergen Van Henegouwen
  • H. De Vries
  • W. Guijt
  • C. A. G. Haasnoot
Original Articles


Norethisterone, a contraceptive 19-norsteroid, was decomposed in aqueous medium (pH 7.4) by UV-B radiation (280-320 nm). This 4-en-3-oxo-19-norsteroid was not prone to the skeletal rearrangement reactions usually observed in steroids possessing a C10-methyl group. Under the reaction conditions applied, products were formed by addition of molecules, such as solvent molecules or a second steroid molecule, and by reduction of the double bond. The prevalence of addition type reactions may have consequences for the application of norethisterone-like steroids in subdermal contraceptive devices.


Public Health Steroid Internal Medicine Double Bond Aqueous Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Bohn, Scheltema & Holkema 1985

Authors and Affiliations

  • A. G. J. Sedee
    • 1
  • G. M. J. Beijersbergen Van Henegouwen
    • 1
  • H. De Vries
    • 1
  • W. Guijt
    • 2
  • C. A. G. Haasnoot
    • 2
  1. 1.Department of Pharmacochemistry, Center for Bio-Pharmaceutical SciencesState University of LeidenRA LeidenThe Netherlands
  2. 2.Laboratory of Biophysical Chemistry, Faculty of ScienceUniversity of NijmegenED NijmegenThe Netherlands

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