Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 1470–1473 | Cite as

Biopharmaceutical studies of fatty suspension suppositories

IV. Influence of particle size on bioavailability of pentobarbital sodium in humans
  • J. J. Rutten-Kingma
  • D. D. Breimer
  • C. J. De Blaey


The bioavailability of pentobarbital sodium was studied in humans, as a function of the size of particles dispersed in fatty suppositories. It was found that particles of 90–100Μm exhibit a faster absorption rate compared with particles smaller than 20Μm. This confirms earlier findings on watersoluble compoundsin vitro as well asin vivo in rats. It seems therefore advisable to consider a lower limit for drug particles in suppositories for readily watersoluble compounds.


Pentobarbital Sodium Direct Compression Hexobarbital Partment Linear Model Pharmaceutisch Weekblad Scientific Edition 
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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • J. J. Rutten-Kingma
    • 1
  • D. D. Breimer
    • 1
  • C. J. De Blaey
    • 1
  1. 1.Dept. of Pharmaceutics and Pharmacology, Subfaculty of PharmacyUniversity of Leiden, Gorlaeus LaboratoriaRA LeidenThe Netherlands

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