An evaluation of the compression characteristics of some magnesium carbonate granulations
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The relationship between applied pressure and the resulting compact density has been investigated for magnesium carbonate granulated with a number of commonly used granulating agents at a range of concentrations. The resultant data are treated using theHeckel and theCooper andEaton equations. The latter proves unsuitable, but the former gives a rectilinear relationship between pressure and density over a considerable pressure range. The slopes of these lines increase with increasing amount of granulating agent up to a limiting value, beyond which no further increase is obtained. The results are discussed in relation to the plasticity of the granulations.
KeywordsAcetylsalicylic Acid Compression Pressure Wheat Starch Yield Pressure Compact Density
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- Armstrong, N. A., andR. F. Haines-Nutt (1970)J. Pharm. Pharmacol. 22, 8S.Google Scholar
- Armstrong, N. A., andF. S. S. Morton (1977)J. Powder and Bulk Solids Technology 1, 32.Google Scholar
- Baba, M., andN. Nagafuji (1965)Ann. Report Shionogi Res. Lab. 15, 147.Google Scholar
- De Blaey, C. J., andJ. Polderman (1970)Pharm. Weekblad. 105, 241.Google Scholar
- Heckel, R. W. (1961)Trans. Met. Soc. AIME 22I, 671.Google Scholar
- Hersey, J. A., andJ. E. Rees (1970)Particle Size Analysis Conference, Bradford.Google Scholar
- Lewis, C. J., andE. Shotton (1965)J. Pharm. Pharmacol. 17, 71S.Google Scholar