The present study compares the determination of the plasma concentrations of ampicillin, amoxycillin and cefuroxime in rabbits, by means of high performance liquid chromatography and the microbiological assay. The correlation coefficient between the data obtained by these methods are for ampicillin 0.991, amoxycillin 0.994 and cefuroxime 0.991.
Plasma constituents interfering with amoxycillin in theHplc determinations, were not encountered in the plasma of man.
High Performance Liquid Chromatography Cefuroxime Amoxycillin Netilmicin High Performance Liquid Chromatography Method
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Anhalt, J. P. (1977) Assay of gentamicin in serum by high pressure liquid chromatography,Antimicrob. Agents Chemotherap. II, 651–655.CrossRefGoogle Scholar
Buhs, R. P., T. E. Maxim, N. Allen, T. A. Jacob andF. J. Wolf (1974) Analysis of cefoxitin, cephalothin and their deacylated metabolites in human urine by high performance liquid chromatography,J. Chromatog. 99 609–618.CrossRefGoogle Scholar
Butterfield, A. G., D. W. Hughes, N. J. Pound andW. L. Wilson (1973) Separation and detection of tetracyclines by high speed chromatography,Antimicrob. Agents Chemotherap. 4, 11–15.CrossRefGoogle Scholar
Dalen, R. Van, T. B. Vree, J. C. M. Hafkenscheid andJ. S. F. Gimbrère (1979) Determination of plasma and renal clearance of cefuroxime and its pharmacokinetics in renal insufficiency,Antimicrob. Chemotherap., in press.Google Scholar
Diasio, R. B., M. E. Wilburn, S. Shadomy andA. Espinelingroff (1978) Rapid determination of serum 5-Fluorocytosine levels by High Performance Liquid Chromatography,Antimicrob. Agents Chemotherap. 13, 500–504.CrossRefGoogle Scholar
Lötscher, K. M., B. Brander andH. Kern (1974)Liquid chromatographic analysis of antibiotics. Application note no. 6, Varian.Google Scholar
Maitra, S. K., T. T. Yoshikawa, J. L. Hansen, I. Nilsson-Eh-Le, W. J. Palin, M. C. Schotz andL. B. Guze (1977) Serum gentamicin Assay by High Performance Liquid Chromatography,Clin. Chem. 23, 2275–2278.PubMedGoogle Scholar
Nilsson-Ehle, I. (1977) High Pressure liquid chromatography as a tool for determination of antibiotics in biological fluids,Acta Pathol. Microbiol. Scand, Section B. Supplement259, 61–66.Google Scholar
Nilsson-Ehle, I., T. T. Yoshikawa, M. C. Schotz andL. B. Guze (1978a) Quantitation of antibiotics by High-Pressure Liquid Chromatography: Cephalotin,Antimicrobiol. Agents Chemotherap. 13, 221–227.CrossRefGoogle Scholar
Nilsson-Ehle, I., G. Kahlmeter andP. Nilsson-Ehle (1978b) Determination of chloramphenicol in serum and cerebrospinal fluid with high pressure liquid chromatography,Antimicrobial. Chemother. 4, 169–176.CrossRefGoogle Scholar
Peng, G. W., G. G. Jackson andW. L. Chiou (1977) High-Pressure Liquid chromatography Assay of Netilmicin in plasma,Antimicrobiol. Agents Chemotherap. 12, 707–709.CrossRefGoogle Scholar
Rolewics, T. F., B. L. Mirkin, M. J. Cooper andH. W. Anders (1977) Metabolic disposition of cephalotin and deacetylcephalotin in children and adults: comparison of high performance liquid chromatographic and microbial assay procedures,Clin. Pharmacol. Therap. 22, 928–935.CrossRefGoogle Scholar
Vree, T. B., Y. A. Hekster, A. M. Baars andE. Van Der Kleijn (1978a) Rapid determination of amoxycillin (Clamoxyl®) and ampicillin (Penbritin®) in body fluids of man, by means of high performance liquid chromatography,J. Chromatog. Biomed. Appl. 145, 496–501.CrossRefGoogle Scholar
Vree, T. B., Y. A. Hekster, A. M. Baars, J. E. Damsma andE. Van Der Kleijn (1978b) Determination of trimethoprim and sulfamethoxazole (Co-trimoxazole) in body fluids of man by means of high performance liquid chromatography,J. Chromatog. Biomed. Appl. 146, 103–112.CrossRefGoogle Scholar
Wheeler, L. A., M. De Meo, M. Halula, L. George andP. Heseltine (1978) Use of high-pressure liquid chromatography to determine plasma levels of metronidazole and metabolites after Intravenous administation,Antimicrob. Agents Chemotherap. 13, 205–209.CrossRefGoogle Scholar