Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 449–456 | Cite as

Some aspects of the polymorphism and stability of acetohexamide

  • B. W. Müller
  • M. Lagas
Short Communications


Two polymorphic forms of acetohexamide have been characterised using differential scanning calorimetry, scanning electron microscopy and X-ray diffraction. For both polymorphic forms the dissolution rates and solubilities have been investigated. The phosphate buffer (pH 7.6) prescribed in the usp xix as the medium for the dissolution test of acetohexamide tablets cannot be used, because a less soluble potassium salt crystallises during the dissolution process.


Dissolution Rate Anthraquinone Dissolution Medium Potassium Salt Polymorphic Form 
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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • B. W. Müller
    • 1
  • M. Lagas
    • 1
  1. 1.Laboratory for Pharmaceutical TechnologyState UniversityGroningenThe Netherlands

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