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Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 449–456 | Cite as

Some aspects of the polymorphism and stability of acetohexamide

  • B. W. Müller
  • M. Lagas
Short Communications
  • 23 Downloads

Abstract

Two polymorphic forms of acetohexamide have been characterised using differential scanning calorimetry, scanning electron microscopy and X-ray diffraction. For both polymorphic forms the dissolution rates and solubilities have been investigated. The phosphate buffer (pH 7.6) prescribed in the usp xix as the medium for the dissolution test of acetohexamide tablets cannot be used, because a less soluble potassium salt crystallises during the dissolution process.

Keywords

Dissolution Rate Anthraquinone Dissolution Medium Potassium Salt Polymorphic Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Burger, A. (1975a)Sci. Pharm. 43, 152; (1975b)Ibidem 43, 161.Google Scholar
  2. Girgis-Takla, P., andI. Chroneos (1977)J. Pharm. Pharmacol. 29, 640.CrossRefPubMedGoogle Scholar
  3. Kissinger, H. E. (1957)Anal. Chem. 29, 1702.CrossRefGoogle Scholar
  4. Shafer, C. E. (1972) in:Analytical Profiles of Drug Substances, Vol. 1. Academic Press, London-New York, p. 1–14.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • B. W. Müller
    • 1
  • M. Lagas
    • 1
  1. 1.Laboratory for Pharmaceutical TechnologyState UniversityGroningenThe Netherlands

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