Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 443–449 | Cite as

The essential oil of Valeriana officinalis L. s.l.

  • B. Hazelhoff
  • D. Smith
  • Th. M. Malingré
  • H. Hendriks


The pharmacological action of Valerian is mainly ascribed to the so-called valepotriates, which were first shown to be present in Valerian ByThies (1966).

An investigation into the composition of the essential oil of subterranean parts of a commercial Valerian strain has been carried out in order to obtain a clearer insight into its possible contribution to the pharmacological action of this plant. During this investigation, mainly performed by means ofGc-Ms, 69 compounds could be identified of which 45 had not been reported to be present in the essential oil of European Valerian.

Three types of essential oil could be distinguished in a comparative investigation of a number of samples of root material from individual plants, namely: Type A: 2.4–4.9% elemol, 6.2–8.7% valeranone and 13.4–15.9% valerenal; no ‘M = 238’ and ‘M = 280’. Type B: 9.8–11.7% elemol, 10.3–12.0% valerenal; no valeranone, ‘M = 238’ and ‘M = 280’. Type C: 1.9–2.8% elemol, 16.2–18.1% valeranone, 9.3–10.3% ‘M = 238’, 3.3–3.9% valerenal and 3.3–3.8% ‘M = 280’. ‘M = 238’ and ‘M = 280’ are presumably a kessyl alcohol and its corresponding acetate respectively.

From the results obtained the conclusion can be drawn that, if the essential oil of Valerian plays a role in the pharmacological action of the crude drug, it depends upon the composition of the essential oil.

An extended investigation has to be carried out in order to define the original chemotypes ofValeriana officinalis L. s.l.


Isovalerate Bornyl Bornyl Acetate Pharmaceutisch Weekblad Scientific Edition Citronellyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Dutch Pharmacopoeia, Edition VI, second printing (1966) Staatsuitgeverij, 's-Gravenhage, p. 72.Google Scholar
  2. Eickstedt, K. W. Von (1969)Arzneimittelforsch, 19, 993.Google Scholar
  3. Eickstedt, K. W. Von, andS. Rahman (1969)Arzneimittelforsch. 19, 316.Google Scholar
  4. Furuya, T., andH. Kojima (1967)J. Chromatog. 29, 341.CrossRefGoogle Scholar
  5. Hazelhoff, B., B. Weert, R. Denee andTh. M. Malingré (1979)Pharm. Weekblad, in preparation.Google Scholar
  6. Hendriks, H. (1973)Planta Med. 24, 158.CrossRefGoogle Scholar
  7. Hendriks, H., D. Smith andB. Hazelhoff (1977)Phytochemistry 16, 1853.CrossRefGoogle Scholar
  8. Hörster, H., G. Rücker andJ. Tautges (1977)Phytochemistry 16, 1070.CrossRefGoogle Scholar
  9. Lemberkovics, E., G. Verzár-Petri, E. Pethes andK. Mikita (1977)Sci. Pharm. 45 (4), 281.Google Scholar
  10. Nen 5363-11 (1966)Essential Oils, Methods of test. Nederlands Normalisatie Instituut, p. 7.Google Scholar
  11. Pethes, E., G. Verzár-Petri, K. Mikita andE. Lemberkovics (1975)Sci. Pharm. 43 (3), 173.Google Scholar
  12. Rücker, G., andJ. Tautges (1976)Phytochemistry 15, 824.CrossRefGoogle Scholar
  13. Rücker, G., J. Tautges, A. Sieck, H. Wenzl andE. Graf (1978)Arzneimittelforsch. 28, 7.PubMedGoogle Scholar
  14. Schaette, R. (1971)Zur Wertbestimmung, Pharmakologie und umweltbedingten Wirkstoffbildung von Radix Valerianae. Thesis, Ludwig Maximilians-Universität, München.Google Scholar
  15. Stenhagen, E., S. Abrahamsson andF. W. Mclafferty (1974)Registry of mass spectral data. J. Wiley & Sons, New York — Sydney — London — Toronto.Google Scholar
  16. Takamura, K., H. Nabata andM. Kawaguchi (1975)Yakugaku Zasshi 95 (10), 1205.PubMedGoogle Scholar
  17. Tautges, H. J. (1976)Untersuchungen über Sesquiterpene aus Nardostachys jatamansi DC. Thesis, Westfälische Wilhelms-Universität, Münster.Google Scholar
  18. Thies, P. W. (1966)Tetrahedron Letters 11, 1155.CrossRefPubMedGoogle Scholar

Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • B. Hazelhoff
    • 1
  • D. Smith
    • 1
  • Th. M. Malingré
    • 1
  • H. Hendriks
    • 1
  1. 1.Laboratory of PharmacognosyState UniversityGroningenThe Netherlands

Personalised recommendations