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Pharmaceutisch weekblad

, Volume 1, Issue 1, pp 436–443 | Cite as

Identification of a lactam by mass spectrometry and proton magnetic resonance spectroscopy

  • G. Huizing
  • A. H. Beckett
  • J. Segura
In Vitro Metabolism of Clebopride

Abstract

Clebopride, a new drug, related to metoclopramide and sulpiride, was incubated with fortified 9000 g supernatant of liver homogenates of maleNzw rabbits.

A lactam,N-(4′-piperidyl-2′-one)-4-amino-5-chloro-2-methoxybenzamide, was identified as a metabolic product, using electron impact (low and high resolution) and field desorption mass spectrometry andCat proton magnetic resonance spectroscopy.

Keywords

Lactam Liver Homogenate Computer Average Time Doxapram Pharmaceutisch Weekblad Scientific Edition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Bohn, Scheltema & Holkema 1979

Authors and Affiliations

  • G. Huizing
    • 1
  • A. H. Beckett
    • 2
  • J. Segura
    • 3
  1. 1.Laboratory for Clinical Pharmacy and ToxicologyCentral Hospital Pharmacy for The HagueThe HagueThe Netherlands
  2. 2.Department of Pharmacy, Chelsea CollegeUniversity of LondonLondonGreat Britain
  3. 3.Division of Biochemistry and BiopharmaceuticsInstitute of Research, Laboratorios Almirall SABarcelona 24Spain

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