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Pharmaceutisch Weekblad

, Volume 8, Issue 6, pp 286–288 | Cite as

Stability after freezing and thawing of solutions of mitomycin C in plastic minibags for intravesical use

  • L. M. L. Stolk
  • A. Fruijtier
  • R. Umans
Original Articles

Abstract

Solutions of 0.6 mg/ml mitomycin C (Mutamycin®) in NaCl solution 0.9% in plastic minibags for intravesical use were stored at −20°C and −30°C and thawed by microwave radiation. Both unbuffered solutions and solutions buffered to approximately pH 7·5 were investigated. Concentrations were measured with HPLC. During freezing and storage at −20°C sometimes crystallization of mitomycin C occurred. However, both buffered and unbuffered solutions could be frozen at −30°C during at least four weeks and subsequently thawed without loss of content. Unbuffered mitomycin C solutions could be refrozen at −30°C for another four weeks. Also buffered and unbuffered solutions of another brand of mitomycin C (Mitomycin-C Kyowa®) could be frozen at −30°C during four weeks without significant deterioration.

Key words

Drug stability Mitomycin C Freezing Quantitative analysis Sterilization Thawing, microwave radiation 

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Copyright information

© Bohn, Scheltema & Holkema 1986

Authors and Affiliations

  • L. M. L. Stolk
    • 1
  • A. Fruijtier
    • 2
  • R. Umans
    • 3
  1. 1.Department of PharmacyAcademic Medical CentreAmsterdamThe Netherlands
  2. 2.Department of PharmacyState University of UtrechtUtrechtThe Netherlands
  3. 3.Department of Pharmacy, Division of PharmacotherapyUniversity of AmsterdamAmsterdamThe Netherlands

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